Seminars in Hearing Research (3/31/22) - Wei-Ming Yu
Seminars in Hearing Research (3/31/22) - Wei-Ming Yu
Author: | M. Heinz |
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Event Date: | March 31, 2022 |
Hosted By: | Hari Bharadwaj |
Time: | 1030-1120 |
Location: | LYLE 1150 |
Contact Name: | Bharadwaj, Hari M |
Contact Email: | hbharadw@purdue.edu |
Open To: | All |
Priority: | No |
School or Program: | Biomedical Engineering |
College Calendar: | Show |
Seminars in Hearing Research at Purdue (SHRP)
Seminar presented in conjunction with the Purdue Biological Sciences Seminar Series (Neurobiology & Physiology Area).
Date: Thursday, March 31, 2022
Time: 10:30 – 11:20 am
Location: Zoom only
Zoom info:
https://purdue-edu.zoom.us/j/93108158900?pwd=RDdTQ0Z4UE9Rb0JUenhjMG1SMkp2QT09
Meeting ID: 931 0815 8900
Passcode: 11501150
Speaker: Wei-Ming Yu, Ph.D., Loyola University, Chicago, IL
Host: Donna M. Fekete, Ph.D., Purdue University
Title: Ephrin-Eph forward signaling in tonotopic map formation in the mouse cochlear nucleus
Abstract: Tonotopy is a fundamental feature of the vertebrate auditory system and forms the basis for sound discrimination, but the molecular basis underlying its formation remains largely elusive. Ephrin/Eph signaling is known to play important roles in topographic mapping in other sensory systems. Here, we found that ephrin-A3 molecules are differentially expressed along the tonotopic axis in developing mouse cochlear nucleus. Ephrin-A3 forward signaling is sufficient to repel auditory nerve fibers in a developmental stage-dependent manner. In ephrin-A3 mutant animals, the tonotopic map is degraded and isofrequency bands of neuronal activation upon pure tone exposure become imprecise in the anteroventral cochlear nucleus. Ephrin-A3 mutant mice exhibit a delayed second wave in auditory brainstem responses and impaired detection sound frequency changes. Our findings establish an essential role of ephrin-A3 forward signaling in forming precise tonotopy in the mouse cochlear nucleus to ensure accurate sound discrimination.
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The working schedule for this academic is here:
https://purdue.edu/TPAN/hearing/shrp_schedule
The titles and abstracts of the talks will be added here:
https://purdue.edu/TPAN/hearing/shrp_abstracts