Skip navigation
Linnes Lab

Publications

A full list of publications and citation statistics for Dr. Jacqueline C. Linnes is provided on Google Scholar.

Peer Reviewed Publications

  1. M Fratus, J Lim, J Nolan, E Madsen, Y Dai, CH Lee, JC Linnes, H Lee, MA Alam+. “Geometry-defined Response Time and Sensitivity for Microneedle-based Amperometric Sensors”, IEEE Sensors, Accepted May 16, 2023
  2. A Desai, D Tankasala, GP Ng, PR Thakkar, OS Hoilett, K Mather, JC Linnes+, “Selective collection of exhaled breath condensate for non-invasive screening of breath glucose” Journal of Diabetes Science and Technology, Accepted May15, 2023
  3. NM Rodriguez, G Burleson, JC Linnes+, K Sienko+ “Thinking Beyond the Device: An Overview of Human- and Equity-Centered Approaches for Improved Health Technology Design”, Annual Review of Biomedical Engineering, 2023. 25: 257–79. doi: 10.1146/annurev-bioeng-081922-02483
  4. N Sritong, M Sala de Medeiros, LAW Basing, JC Linnes+, “Promise and perils of paper-based point-of-care nucleic acid detection for pandemic pathogens”, Lab on a Chip, 2023, 23, 888-912. doi: 10.1039/D2LC00554A
  5. DH Lee, KN Clayton, TL Kinzer-Ursem, JC Linnes, ST Wereley+, “Quantifying Brownian Motion in the Presence of Simple Shear Flow with Particle Diffusometry”, Experiments in Fluids, 2023, 64(2):26. doi: 10.1007/s00348-022-03566-8
  6. DH Lee, E Madsen, JC Linnes, ST Wereley+, “Temporally and spatially resolved micro-rheometry of a transient viscous polymer formation”, Measurement Science and Technology, 2022, Dec 21; 34:035301. doi: 10.1088/1361-6501/aca993
  7. JD Berwanger*, MA Lake*, HY Tan, S Ganguly, CJ Welch, JC Linnes, M Bruening+. “Microporous Affinity Membranes and their Incorporation into Microfluidic Devices for Monitoring of Therapeutic Antibodies”, Talenta, 2023, Jan 15; 252:123842. doi: 10.1016/j.talanta.2022.123842
  8. H Ma, ST Wereley, JC Linnes+, TL Kinzer-Ursem+. “Measurement of protein-protein interaction dynamics using microfluidics and particle diffusometry,” Analytical Chemistry, 2022, 94(45):15655–15662, doi: 10.1021/acs.analchem.2c02570
  9. EI Newsham, EA Phillips, H Ma, MM Chang, ST Wereley, JC Linnes+ “Characterization of wax valving and μPIV analysis of microscale flow in paper-fluidic devices for improved modeling and design” Lab Chip, June 2022, 22, 2741-2752, Doi: 10.1039/D2LC00297C
  10. AJ Colbert, DH Lee, KN Clayton, ST Wereley, JC Linnes+, TL Kinzer-Ursem+. “PD-LAMP smartphone detection of SARS-CoV-2 on Chip” Analytica Chemica Acta. April 2022, 1203:339702. Doi: 10.1016/j.aca.2022.339702
  11. AE Lottes, KJ Cavanaugh Jr, YY-F Chan, VJ Devlin, CJ Goergen, R Jean, JC Linnes, M Malone, R Pea, DG Reuter, K Taylor, GR Wodicka. “Navigating the Regulatory Pathway for Medical Devices—a Conversation with the FDA, Clinicians, Researchers, and Industry Experts”.  Journal of Cardiovascular Translational Research, 2022, doi: 10.1007/s12265-022-10232-1
  12. E Nwanochie, JC Linnes+. “Review of Non-Invasive Detection of SARS-CoV-2 and Other Respiratory Pathogens in Exhaled Breath Condensate” Journal of Breath Research, 2022. Mar 18;16(2):10.1088/1752-7163/ac59c7. doi: 10.1088/1752-7163/ac59c7
  13. HY Tan, J Yang, JC Linnes, CJ Welch, ML Bruening+. “Quantitation of Trastuzumab and an Antibody to SARS-CoV‑2 in 2 Minutes Using Affinity Membranes in 96-Well Plates,” Analytical Chemistry, Jan 4, 2022. doi: 10.1021/acs.analchem.1c03654
  14. AJ Colbert, K Co, G Lima-Cooper, DH Lee, KN Clayton, ST Wereley, CC John, JC Linnes+, TL Kinzer-Ursem+. “Towards the use of a smartphone imaging-based tool for point-of-care detection of asymptomatic low-density malaria parasitaemia.” Malaria Journal. 2021 Sep 25;20(1):380. doi: 10.1186/s12936-021-03894-w
  15. MM Gilligan, JC Linnes, JE Von Oettingen, K Altenor+. “From Toy to Tool: Using Water Beads for Insulin Storage” Pediatric Diabetes, December 1, 2020 doi: 10.1111/pedi.13167
  16. TJ Moehling, DH Lee, ME Henderson, MK McDondald, PH Tang, ES Kim, ST Wereley, TL Kinzer-Ursem, KN Clayton+, JC Linnes+. “A Smartphone-Based Particle Diffusometry Platform for Sub-Attomolar Detection of Vibrio cholerae in Environmental Water”, Biosensors and Bioelectronics, 2020, 167, 112497; doi:10.1016/j.bios.2020.112497

  17. OS Hoilett, JF Walker, BM Doehrman, NJ Jaras, S Boppana, JC Linnes, "KickStat: A Versatile Miniaturized Potentiostat to Democratize Electrochemical Research," Sensors, 2020, 20(8), 2407; doi: 10.3390/s20082407

  18. LA Basing, SV Simpson, Y Adu-Sarkodie, JC Linnes, “A Loop-Mediated Isothermal Amplification (LAMP) assay for the detection of Treponema pallidum subsp. pertenue,” American Journal of Tropical Medicine & Hygiene, 2020, 103(1), 253; doi:10.4269/ajtmh.19-0243

  19. KM Byers*, AR Bird*, H Cho, JC Linnes, “Fully Dried ELISA with Novel Two-Dimensional Paper Network for Detection of Amplified Nucleic Acids”, ACS Omega, 2020, doi:10.1021/acsomega.0c00115

  20. KM Byers, LK Lin, L Stanciu, JC Linnes, “Versatile Printed Microheaters to Enable Low-Power Thermal Control in Paper Diagnostics,” The Analyst, 2020 Doi: 10.1039/c9an01546a

  21. EA Phillips*, TJ Moehling*, KFK Ejendal, OS Hoilett, KM Byers, LA Basing, LA Jankowski, JB Bennett, LK Lin, LA Stanciu, JC Linnes. "Microfluidic Rapid and Autonomous Analytical Device (microRAAD) to Detect HIV from Whole Blood Samples,” Lab on a Chip, 2019. Doi: 10.1039/C9LC00506D (*co-first authors)

  22. B Dhowan, J Lim, MD MacLean, AG Bergman, MK Kim, Q Yang, J Linnes, CH Lee, CJ Goergen, H Lee. “Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose,” Journal of Controlled Release, 2019 May 31:306:130-137. Doi: 10.1016/j.jconrel.2019.05.041

  23. KN Clayton*, T Moehling*, S Wereley, JC Linnes+, T Kinzer-Ursem+, “Particle Diffusometry: An Optical Detection Method for Vibrio cholerae Presence in Environmental Water Samples,” Scientific Reports, 2019 Feb. 9:1739. Doi: 10.1038/s41598-018-38056-7 (*co-first authors, +co-corresponding authors)

  24. EA Phillips, T Moehling, A Ellington, S Bhadra, JC Linnes, “Strand displacement probes combined with isothermal nucleic acid amplification for instrument-free detection from complex samples,” Analytical Chemistry, 2018. 90(11): 6580–6586. Doi: 10.1021/acs.analchem.8b00269

  25. A Horst, NL Kolluri, JM Rosenbohm, J Hardick, C Gaydos, M Cabodi, CM Klapperich, JC Linnes, “A paper-fluidic platform to detect Neisseria gonorrhoeae in clinical samples,” Biomedical Microdevices, 2018. 20:2, 35-41. Doi: 10.1007/s10544-018-0280-x

  26. KN Clayton, G Berglund, JC Linnes, S Wereley, T Kinzer-Ursem. “DNA microviscosity characterization with particle diffusometry for downstream DNA detection applications”, Analytical Chemistry, 2017. Doi: 10.1021/acs.analchem.7b03513

  27. EA Phillips, S Zhao, R Shen, JC Linnes. "Thermally actuated wax valves for paper-fluidic diagnostics," Lab on a Chip, 2016. 16, 4230-4236. Doi:  10.1039/c6lc00945j

  28. JC Linnes, NM Rodriguez, L Liu, CM Klapperich. "Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics," Biomedical Microdevices, 2016. 18 (2), 1-12. Doi: 10.1007/s10544-016-0057-z

  29. NM Rodriguez, JC Linnes, A Fan, CK Ellenson, CM Klapperich. “Paper-based RNA extraction, in situ isothermal amplification, and lateral flow detection for low-cost, rapid diagnosis of Influenza A (H1N1) from clinical specimens,” Analytical Chemistry, 2015. 87 (15), 7872-7879. Doi: 10.1021/acs.analchem.5b01594

  30. R Derda, J Gitaka, TM Kariuki, CM Klapperich, CR Mace, AA Kumar, M Lieberman, JC Linnes, J Nasimolo, J Ndung’u, E Taracha, A Weaver, DB Weibel, P Yager. “Enabling the development and deployment of next generation point of care diagnostics,” PLOS Neglected Tropical Diseases, 2015. 9 (5): e0003676. Doi:10.1371/journal.pntd.00036762015

  31. JC Linnes, A Fan, NM Rodriguez, B Lemieux, H Kong, CM Klapperich. “Paper-based molecular diagnostic for Chlamydia trachomatis,” RSC Advances, 2014. 4 (80), 42245 – 51. Doi: 10.1039/c4ra07911f

  32. P Vacas-Jacques, JC Linnes, A Young, V Gerrard, J Gomez-Marquez. “Portable digital lock-in instrument to determine chemical constituents with single-color absorption measurements for Global Health Initiatives,” Review of Scientific Instruments, 2014. 85 (3), 033103. Doi: 10.1063/1.4867097

  33. JC Linnes, SN Rudnick, GM Hunt, JJ McDevitt, EA Nardell. “Eggcrate UV: A whole ceiling upper-room ultraviolet germicidal irradiation system for air disinfection in occupied rooms,” Indoor Air, 2013. Doi: 10.1111/ina.12063

  34. S Miller, JC Linnes, J Luongo. “Ultraviolet germicidal irradiation: Future directions for air disinfection and building applications,” Photochemistry and Photobiology, 2013. 89(4) 777-81. Doi: 10.1111/php.1208

  35. JC Linnes, H Ma, JD Bryers. “Giant extracellular matrix binding protein gene and protein expression in Staphylococcus epidermidis is regulated by biofilm formation and osmotic pressure,” Current Microbiology, 2013. 66(6) 627-33. Doi: 10.1007/s00284-013-0316-7

  36. JC Linnes, K Mikhova, JD Bryers. “Adhesion of Staphylococcus epidermidis to biomaterials is inhibited by firbronectin and albumin,” Journal of Biomaterials Research Part A. 2013. 100(8) 1990-7. Doi: 10.1002/jbm.a.34036

  37. *D Alexander, *JC Linnes, S Bolton, T Larson. “Ventilated cookstoves improve respiratory health-related quality of life in rural Bolivia,” Journal of Public Health, 2013. 36 (3) 460-466 (*equal authorship) Doi: 10.1093/pubmed/fdt086

  38. J Callihan, R Roeder, LA Geddes, M Otlewski, A Kemeny. “Ventricular fibrillation frequency,” Pacing and Clinical Electrophysiology, 2006. 28(7) 610-612. Doi: 10.1111/j.1540-8159.2005.00166.x

Book Chapters

  1. JC Linnes, E Johansen, AA Kumar, “Incorporating the Needs of Users in the Development of Diagnostics for Global Health: A Framework and Two Case Studies", in Diagnostic Devices with Microfluidics. Ed. by F. Piraino and S. Selimovic. CRC Press, Boca Raton, FL 2017.

  2. JC Linnes, E Phillips, “Thermally Actuated Wax Vales for Multistep Diagnostics", in Diagnostic Devices with Microfluidics. Ed. by F. Piraino and S. Selimovic. CRC Press, Boca Raton, FL 2017.

  3. Y Fu, SH Jeong, J Callihan, J Kim, K Park, “Preparation of Fast-dissolving Tablets Based on Mannose”, in Polymeric Drug Delivery II, Ed. By S. Svenson. American Chemical Society, Washington DC 2006.

Conference Proceedings

  1. H Ma, ST Wereley, JC Linnes, TL Kinser-Ursem. “Measurement of kinetic constant of protein binding using microfluidics and particle diffusometry” 14th International Symposium on Particle Image Velocimetry. 2021 August 1-5, Virtual. DOI: 10.18409/ispiv.v1i1.75
  2. DH Lee, KN Clayton, TJ Moehling, TL Kinzer-Ursem, JC Linnes, ST Wereley. “Particle Diffusometry: PIV based method for Pathogen Detection on Smartphone-Based Platform. 13th International Symposium on Particle Image Velocimetry, 2021 July 22-24 Munich Germany.

  3. ND Bluhm, OS Hoilett, BD Walters, AS Pickering, JC Linnes, S Bucher. “NeoWarm: Kangaroo Mother Care with Continuous Temperature Tracking and Heating”, Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2020 July 20-24, Montreal, Quebec, CN (Accepted)

  4. J Ummel, OS Hoilett, BD Walters, ND Bluhm, AS Pickering, D Wilson, JC Linnes. “Kick Ring LL: A Multi-Sensor Ring Capturing Respiration, Electrocardiogram, Oxygen Saturation, and Skin Temperature”, Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2020 July 20-24, Montreal, Quebec, CN  (Accepted)

  5. OS Hoilett, AM Twibell, R Srivastava, JC Linnes. “Kick LL: A Smartwartch for Monitoring Respiration and Heart Rate using Photoplethysmography,” Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018 July 17-21; Honolulu, Hawaii, USA

  6. D Tankasala, GP Ng, MS Smith, JR Bendell, JC Linnes. “Selective Collection and Condensation of Exhaled Breath for Glucose Detection,” Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018 July 17-21; Honolulu, Hawaii, USA

  7. OS Hoilett, AF Aboelzahab, EA Layow, JC Linnes, CH Lee. “#FunTimesWithTheTA—A Series of Fun Supplementary Lessons for Introductory Level Biomedical Instrumentation Students, Part II (Work in Progress),” Proceedings of the 2018 ASEE Annual Conference & Exposition, 2018 June 24, Salt Lake City, UT, USA

  8. Q Yang, T Nguyen, C Liu, J Miller, J Rhoads, JC Linnes, H Lee. “Polyimide-Based Magnetic Microactuators for Biofouling Removal,” Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2016 August 16; Tampa, FL, USA

  9. OS Hoilett, AF Aboelzahab, EA Layow, JC Linnes, CH Lee. “#FunTimesWithTheTA—A Series of Fun Supplementary Lessons for Introductory Level Biomedical Instrumentation Students (Work in Progress),” Proceedings of the 2017 ASEE Annual Conference & Exposition, 2017 June 24, Columbus, OH, USA

  10. C Matlack, H Chizeck, T Davis, JC Linnes. “A Low-cost Solar Disinfection Indicator for Safe Water,” Proceedings of the 2011 IEEE Global Humanitarian Technology Conference, 2011. GHTC 283-286, Seattle, WA, USA

Issued Patents

  1. "Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent (method). 11,628,434. JC Linnes, R Shen, M Chiu. Filed 08/13/2021. Issued 04/18/2023
  2. “Method of Monitoring Respiratory Rate In A Health Monitoring Device” US Patent. 11,633,152. JC Linnes, OS Hoilett, B Walters. Filed 10/16/2020. Issued 04/25/2023
  3. "Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent (system). 11,529,626. JC Linnes, R Shen, M Chiu. Filed 10/26/2017. Issued 08/17/2021
  4. “Fluidic Control Elements for Signal Readout Enhancement In Two Dimensional Paper Networks” US Patent 11047853. JC Linnes, LM Jamicich, EA Phillips, KM Byers, AR Bird. Filed 01/19/2018. Published 07/19/2018. Issued 06/29/2021
  5. “Methods for Detecting Heart Rate, Respiration, Heart Rate, and Oxygen Saturation and Uses Thereof” US Patent 10,786,201. HW Lee, JC Linnes, OS Hoilett, AM Twibell, R Srivastava, R Lindsey, J Ummel. Filed 10/12/2018. Issued 9/29/2020
  6. “Temperature Controlled Valves for Paper-based Microfluidic Systems” US Patent. 11,090,649. JC Linnes, R Shen, M Chiu. Filed 10/26/2017. Issued 08/17/2021
  7. “Methods of measuring structural and functional changes of a biomolecular composition” US Patent. 11,221,287. ST Wereley, TL Kinzer-Ursem, KN Clayton, JC Linnes, D Lee, T Moehling. Filed 12/19/17. Issued 01/11/2022
  8. “Detection Device Having Capture Region and Detection Region” US Patent. 11136620B2. CM Klapperich, NM Rodriguez, JC Linnes. Filed 06/16/2016. Issued 10/05/2021
  9. “Systems, devices and methods for multiplexed diagnostics” US Patent. 9,488,613. I Bosch, L Gherke, J Gomez-Marquez, K Hamad-Schifferli, NC Hanoumara, JC Linnes, DK Wood. Filed 08/30/2013. Issued 11/08/2016
  10. “Mannose based fast dissolving tablets" International Patent. JP 2004555820A. Y Fu, SH Jeong, J Kim, J Callihan, CM Pai, SY Park, G Seomoon, K Park, Filed 11/25/2003. Issued 09/29/2019
  • 3 Proprietary licenses assigned directly to company as part of research contracts

Copyrights Filed

  1. “ KICKR_INO_Device-Code” US Copyright Application 1-7035967441. HW Lee, JC Linnes, OH Hoilett, AM Twibell, R Srivastava. Filed 10/15/2018
  1. “Solar Disinfection of Fluid” US Patent. 9,868,651. CB Matlack, TB Davis, JC Linnes. Filed 12/29/2015. Issued 01/16/2018
  2.