{"id":14,"date":"2014-09-03T18:52:37","date_gmt":"2014-09-03T18:52:37","guid":{"rendered":"https:\/\/Engineering.Purdue.Edu\/LIMR\/?page_id=14"},"modified":"2021-10-12T14:17:12","modified_gmt":"2021-10-12T19:17:12","slug":"research","status":"publish","type":"page","link":"https:\/\/engineering.purdue.edu\/LIMR\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

RESEARCH<\/strong><\/h4>\n

Actuators<\/strong><\/h2>\n

<\/p><\/h1><\/div><\/div><\/div>

<\/hr><\/div><\/div><\/div>

Magnetic microactuator enabled <\/strong>self-clearing catheters<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Yang, Q., Park, H., Nguyen, T. N. H., Rhoads, J. F., Lee, A., Bentley, R. T., Judy, J. W., and Lee, H. Anti-biofouling implantable catheter using thin-film magnetic microactuators. Sensors and Actuators B: Chemical, 273,<\/em> pp. 1694-1704, 2018.<\/a><\/p>\n

Yang, Q., Lee, A., Bentley, R. T., and Lee, H. Piezoeresistor-embedded multifunctional magnetic microactuators for implantable self-clearing catheter. IEEE Sensors Journal, 19, 4<\/em>, pp. 1373-1378, 2019.<\/a><\/p><\/div><\/div>

Smart glaucoma drainage devices\u00a0<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Park, H., Raffiee, A. H., John, S. W. M., Ardekani, A. M., and Lee, H. Towards smart self-clearing glaucoma drainage device. Microsytems and Nanoengineering, 4,<\/em> 35, 2018.<\/a><\/p><\/div><\/div><\/div><\/div>

Automatic antidote delivery system for treatment of opioid overdose<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Dhowan, B., Lim, J., MacLean, M. D., Berman, A. G., Kim, M. K,, Yang, Q., Linnes, J., Lee, C. H., Goergen, C. J., Lee, H. Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose. Journal of Controlled Release, 306,<\/em> pp. 130-137, 2019.<\/a><\/p><\/div><\/div>

Magnetic actuator-enabled 3D\u00a0cell culture\u00a0system for cancer research<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>
Enr\u00edquez, \u00c1,\u00a0Libring, A., Field, T. C., Jimenez, J., Lee, T., Park, H., Satoski, D., Wendt, M. K., Calve, S., Tepole, A. B., Solorio, L., and Lee, H., High\u2010Throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment, Advanced Functional Materials<\/em>, 2005021, 2020.<\/a><\/div><\/div><\/div><\/div><\/div>

Sensors<\/strong><\/h2><\/h1><\/div><\/div><\/div>
<\/hr><\/div><\/div><\/div>

Printable implantable glutamate biosensor using conductive Pt nanoparticle composite ink<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Nguyen, T. N. H., Nolan, J. K., Park, H., Lam, S., Fattah, M., Joe, H-E, Lee, H., Kim, S. J., Jun, M. B. G., Shi, R., and Lee, H. Facile fabrication of glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. Biosensors and Bioelectronics, 135, 15,<\/em> pp. 257-266, 2019.<\/a><\/p><\/div><\/div>

Activated carbon-Pt based printable\u00a0glutamate biosensor<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Nguyen, T. N. H., Nolan, J. K., Cheng, X., Park, H., Wang, Y., Lam, S., Lee, H., Kim, S. J., Shi, R., Chubykin, A. A. and Lee, H., Fabrication and ex vivo evaluation of activated carbon-Pt microparticle based glutamate biosensor. Journal of Electroanalytical Chemistry<\/em>, 114136, 2020.<\/a><\/p><\/div><\/div><\/div><\/div>

Multi-analyate biosensor array<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Nolan, J.K., Nguyen, T.N., Le, K.V.H., DeLong, L.E. and Lee, H., Simple Fabrication of Flexible Biosensor Arrays Using Direct Writing for Multianalyte Measurement from Human Astrocytes. SLAS TECHNOLOGY: Translating Life Sciences Innovation<\/i>, p.2472630319888442, 2019.<\/a><\/p><\/div><\/div>

CNT-PtNP based \u00a0non-enzymatic glucose biosensor and the non-linear modeling<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>
Nguyen, T. N. H., Jin, X., Nolan, J. K., Xu, J., Le, K. V. H., Lam, S., Wang, Y., Alam, M. A., Lee, H. Printable Nonenzymatic Glucose Biosensors Using Carbon Nanotube-PtNP Nanocomposites Modified with AuRu for Improved Selectivity, ACS Biomaterials Science & Engineering, 6, 9, 5315\u20135325, 2020.<\/a><\/div><\/div><\/div><\/div>

Perovskite-based implantable glutamate biosensor for in vivo cortical monitoring<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Nguyen, T. N. H., Nolan, J. K., Park, H., Lam, S., Fattah, M., Joe, H-E, Lee, H., Kim, S. J., Jun, M. B. G., Shi, R., and Lee, H. Facile fabrication of glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. Biosensors and Bioelectronics, 135, 15,<\/em> pp. 257-266, 2019.<\/a><\/p><\/div><\/div>

<\/div><\/div><\/div><\/div>

Anti-biofouling strategies<\/strong><\/h2><\/h1><\/div><\/div><\/div>
<\/hr><\/div><\/div><\/div>

Simple fabrication technique to create a large-scale, anti-inflammatory biomimetic\u00a0nanotexture\u00a0<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Xu, J., Moon, H., Xu, J., Lim, J., Fischer, T., Mcnally, H. A., Sintim, S. O., and Lee, H. One-step Large-scale Nanotexturing of Non-planar PTFE Surfaces to Induce Bactericidal and Anti-inflammatory Properties, ACS Applied Materials and Interfaces<\/em>, 26893\u201326904, 2020.<\/a><\/p><\/div><\/div>

Novel conductive material towards fabrication of anti-biofouling implantable sensors and actuators <\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Xu, J., Xu, J., Moon, H., Sintim, H.O. and Lee, H., Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics. ACS Applied Polymer Materials<\/em>, 9b00950, 2020.<\/a><\/p>\n

<\/p>\n

Xu, J., Xu. J., Moon, H., Sintim, H. O., and Lee, H., Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial, Journal of Materials Chemistry B<\/em>, 2021.\u00a0<\/a><\/p>\n

Xu, J., and Lee, H. Anti-Biofouling Strategies for Long-Term Continuous Use of Implantable Biosensors, Chemosensors<\/em>, 8(3), 66, 2020.<\/a><\/p>\n

<\/p>\n

<\/p><\/div><\/div><\/div><\/div><\/div>

Neural interface<\/strong><\/h2><\/h1><\/div><\/div><\/div>
<\/hr><\/div><\/div><\/div>

Development of fractal-based neurostimulation\u00a0micro electrodes<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>

<\/p>\n

Park, H, Takmakov, P., and Lee, H. Electrochemical evaluations of fractal microelectrodes for energy efficient neurostimulation. Scientific Reports, 8,<\/em> 4375, 2018.<\/a><\/p><\/div><\/div>

Prevention of Pt-corrosion of micro electrodes using a graphene monolayer<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>
Park, H., Zhang, S., Steinman, A., Chen, Z., and Lee, H.,\u00a0Graphene prevents neurostimulation-induced platinum dissolution in fractal microelectrodes. 2D Materials, 6,<\/em>035037, 2019.\u00a0<\/a><\/div><\/div><\/div><\/div>

In vivo evaluation of novel neural interfaces<\/strong><\/h5><\/h1><\/div><\/div><\/div>\"Image\"<\/span>\"Image\"<\/span>
<\/div><\/div>
<\/div><\/div><\/div><\/div>

Our sponsors<\/strong><\/h2><\/h1><\/div><\/div><\/div>
<\/hr><\/div><\/div><\/div>