Dr. Vladislav Yakovlev Seminar -Seeing life in a new light: from simple classical physics to quantum-enhanced imaging

Abstract:

The progress of biomedical sciences depends on the availability of advanced instrumentation and imaging tools capable of attaining the state of biological systems in vivo without using exogenous markers. Mechanical forces and local elasticity play a central role in understanding physical interactions in all living systems.  We demonstrate a novel way to image microscopic viscoelastic properties of biological systems using Brillouin microspectroscopy [1]. In my talk, I will discuss the ways how an old spectroscopic tool can be used for real time microscopic imaging [2-3] and provide possible solutions to long standing problems in Life Sciences and Medicine [4-6] while advancing instrumentation beyond classical limits [7].

References: 

[1] Zh. Meng, A. Traverso, C. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Advances in Optics and Photonics 8(2), 300-327 (2016).

[2] Zh. Meng, S. C. Bustamante-Lopez, K. E. Meissner and V. V. Yakovlev, “Subcellular imaging of mechanical and chemical properties using Brillouin microspectroscopy,” Journal of Biophotonics 9(3), 201-207 (2016).

[3] C. W. Ballmann, Zh. Meng, A. J. Traverso, M. O. Scully, and V. V. Yakovlev “Impulsive Brillouin microscopy,” Optica 4(1), 124-128 (2017).

[4] Zh. Meng, T. Thakur, C. Chitrakar, M. K. Jaiswal, A. K. Gaharwar, and V. V. Yakovlev, “Assessment of local heterogeneity in mechanical properties of a bulk hydrogel network,” ACS Nano 11(8), 7690–7696 (2017).

[5] M. Troyanova-Wood, Zh. Meng, and V. V. Yakovlev, “Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy,” Biomedical Optics Express 10(4), 1774-1781 (2019).

[6] D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, Zh. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” Journal of Biomedical Optics 23(9), 097004 (2018).

[7] T Li, F Li, X Liu, VV Yakovlev, GS Agarwal, “Quantum-enhanced stimulated Brillouin scattering spectroscopy and imaging,” Optica 9(8), 959-964 (2022)