[Embrio-list] EMBRIO News

[Ladd, Brent Thomas]

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We are looking forward to an engaging Annual Retreat, and productive Summer School, and especially seeing most of you in person the week of July 8th . Our events will be hosted in the Weldon School of Biomedical Engineering. Check these links for updated agendas, poster template, and slide presentation template on our website:

Summer School<https://www.purdue.edu/research/embrio/workforce-development/EMBRIO-summer-school.php>
Annual Retreat<https://www.purdue.edu/research/embrio/research/annual-retreat.php>

Deadlines are coming up Monday to submit poster abstracts and lightning talk slides, along with submissions for the scientific figure competition. With the Independence holiday next week, we won’t be able to extend these deadlines:

Posters & Lightning Talks - Info is Due July 1st
Those presenting posters will also present a 1-minute lightning talk prior to the poster session. These will be organized as much as possible in order by Thrust and lab.
Deadline extension - Due by Monday, July 1st: You will upload your abstract with full citation, along with a one slide PowerPoint for your lightning talk.<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_0qPh2EZ8Nt4EwGq&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=fWTUVnXQBqd%2BXs5autW6V2RXGsmTREKhjRHyvjSpEyI%3D&reserved=0> <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_0qPh2EZ8Nt4EwGq&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=fWTUVnXQBqd%2BXs5autW6V2RXGsmTREKhjRHyvjSpEyI%3D&reserved=0> Your PowerPoint slide may be identical to your poster, or alternatively can include specific aspects or talking points of your poster to highlight. You don't need to upload your poster file. However, plan on bringing your printed poster to the retreat (note that EMBRIO, and the BME department for non-BME students, can't print your poster - no exceptions).

Scientific Figure Competition - Submissions Due July 1st
Submit your scientific figure, live cell video, or model simulation - due by July 1st - for the competition during our annual retreat. There will be two divisions: I. Graduate Students,  II. Postdocs & Staff Research Scientists. Share your best work with the community! Instructions, submission and upload:  https://purdue.ca1.qualtrics.com/jfe/form/SV_6FPX9yViX0tJN66<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_6FPX9yViX0tJN66&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=OubeCuk%2FD9RYwak2h20u7%2FC%2F0c6y%2BW%2Fu2bxBhl5BVyE%3D&reserved=0>

Announcing NEW EMBRIO papers hot off the digital press:
A Cell Reports paper on Piezo including EMBRIO authors Mayesha Mim, Nilay Kumar, David Umulis, Maria Unger, and Jeremy Zartman, is titled “Piezo regulates epithelial topology and promotes precision in organ size and control”<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.celrep.2024.114398&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=jetsC4TThNmWINRhtgoFxHY5NNxy3i6HuOtCCNIhuGQ%3D&reserved=0>. The work shows that Piezo regulates organ size and cell topology by controlling cell tension, cell division, cell death, and tissue properties both locally and non-locally. Piezo ensures precise organ growth by regulating cellular processes and tissue architecture through tension-mediated feedback control of cell division and elimination. This effort helps to lay an initial foundation for ongoing integration with between Thrust 2 and 3.

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Highlights from the paper include:

  *   Piezo regulates the bilateral precision of organ size.
  *   Piezo’s functions include phenotypic effects that span from cells to tissues.
  *   Piezo regulates emergent tissue-level properties both locally and non-locally.
  *   A computational model shows Piezo’s role in linking subcellular processes to growth.


Through an integration of Thrust 1 and 2, a Biophysical Journal Research Highlights paper titled “Proteins clump: Mechanics and transport during neurodegeneration”<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.bpj.2024.06.004&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=WQq9mqY81cK0lI5PcLvGqC1lXOnvOhWQUj%2Fs6o4Wnm8%3D&reserved=0> has been authored by David Gazzo, Tami Kinzer-Ursem, and Jeremy Zartman highlighting new mechanistic insights into key biomechanical and biophysical aspects of neurodegeneration.

EMBRIO members have received awards and promotions recently:

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Stephanie Gardner received the 2024 Charles B. Murphy Award. This is Purdue University’s highest undergraduate teaching award. Congratulations on your many contributions to teaching and curriculum, Steph!! Read about Stephanie’s teaching with undergraduates, and the award.<https://www.purdue.edu/science/about/news/articles/2024/stephanie-gardner-2024-charles-b-murphy-award-winner.html>

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Alejandra Magana has been elected a Fellow of the American Society for Engineering Education (ASEE). Congratulations, Ale, on your many contributions to understanding the processes of learning, problem solving, and innovation across many domains in teaching, and in team science!!

Congratulations on recent faculty promotions for EMBRIO members Tami Kinzer-Ursem, Qing Deng, and GuangJun Zhang were promoted to Full Professor, and to Elsje Pienaar for promotion to Associate Professor!

Upcoming 2024-2025 Staff Promotions include:
Weiwei Zhang is receiving a promotion to Principal Research Scholar with her new title as Senior Plant Cell Biologist.
Brent Ladd is being promoted to a P4 level Managing Director.


Register for the Annual Multicell Virtual-Tissue Modeling Online Summer School and Hackathon
There are several upcoming opportunities for scientific exchange and training found in the Upcoming Dates section, including the Glazier lab will be offering the 19th Annual Multicell Virtual-Tissue Modeling Online Summer School and Hackathon July 28th – Aug. 4th. Applications open. https://compucell3d.org/Workshop24<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcompucell3d.org%2FWorkshop24&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C9c3c55b02dad4ad6c15408dc97ade98b%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638552020410025753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=v8gZYJsiM0dh8DrmV4OEXCiNriQQNsrVRcostxfUsvs%3D&reserved=0>


Brent T. Ladd, Senior Research Program Manager, EMBRIO Institute<https://www.purdue.edu/research/embrio/>
Weldon School of Biomedical Engineering, Purdue University
Office: Hall for Discovery Learning and Research, Ste. 203
207 S. Martin Jischke Drive
West Lafayette, IN 47907
laddb at purdue.edu

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