{"id":504,"date":"2017-11-04T15:38:38","date_gmt":"2017-11-04T20:38:38","guid":{"rendered":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/?p=504"},"modified":"2020-10-17T12:59:36","modified_gmt":"2020-10-17T17:59:36","slug":"m-koester-re-garcia-m-thommes-spheronization-process-particle-kinematics-determined-by-discrete-element-simulations-and-particle-image-velocimetry-measurements-international-journal-of-pha","status":"publish","type":"post","link":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/11\/04\/m-koester-re-garcia-m-thommes-spheronization-process-particle-kinematics-determined-by-discrete-element-simulations-and-particle-image-velocimetry-measurements-international-journal-of-pha\/","title":{"rendered":"M Koester, RE Garc\u00eda, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements.”\u00a0International journal of pharmaceutics, 477(1):81-87, 2014."},"content":{"rendered":"

M Koester, RE Garc\u00eda, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements<\/a>.”\u00a0International Journal of Pharmaceutics, 477(1):81-87, 2014.<\/p>\n

Abstract<\/h3>\n
\n

Spheronization is an important pharmaceutical manufacturing technique to produce spherical agglomerates of 0.5\u20132\u00a0mm diameter. These pellets have a narrow size distribution and a spherical shape. During the spheronization process, the extruded cylindrical strands break in short cylinders and evolve from a cylindrical to a spherical state by deformation and attrition\/agglomeration mechanisms. Using the discrete element method, an integrated modeling-experimental framework is presented, that captures the particle motion during the spheronization process. Simulations were directly compared and validated against particle image velocimetry (PIV) experiments with monodisperse spherical and dry \u03b3-Al2<\/sub>O3<\/sub> particles.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

M Koester, RE Garc\u00eda, M Thommes “Spheronization process particle kinematics determined by…<\/p>\n

Continue reading “M Koester, RE Garc\u00eda, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements.”\u00a0International journal of pharmaceutics, 477(1):81-87, 2014.”<\/span>…<\/a><\/div>\n
Continue reading \"M Koester, RE Garc\u00eda, M Thommes “Spheronization process particle kinematics determined by discrete element simulations and particle image velocimetry measurements.”\u00a0International journal of pharmaceutics, 477(1):81-87, 2014.\"<\/span>…<\/a><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[45],"tags":[79,78,14,77],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/peeeSR-88","jetpack_likes_enabled":true,"jetpack-related-posts":[{"id":488,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/11\/04\/d-w-chung-pr-shearing-np-brandon-sj-harris-re-garcia-particle-size-polydispersity-in-li-ion-batteries-journal-of-the-electrochemical-society-1613a422-a430-2014\/","url_meta":{"origin":504,"position":0},"title":"D-W Chung, PR Shearing, NP Brandon, SJ Harris, RE Garc\u00eda “Particle Size Polydispersity in Li-Ion Batteries.”\u00a0Journal of The Electrochemical Society, 161(3):A422-A430, 2014.","date":"11\/04\/2017","format":false,"excerpt":"D-W Chung, PR Shearing, NP Brandon, SJ Harris, RE Garc\u00eda \"Particle Size Polydispersity in Li-Ion Batteries.\"\u00a0Journal of The Electrochemical Society, 161(3):A422-A430, 2014. Abstract Starting from three-dimensional X-ray tomography data of a commercial LiMn2O4\u2009battery electrode, the effect of microstructure on the electrochemical and chemo-mechanical response of lithium-ion batteries is analyzed. Simulations\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":871,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2020\/10\/17\/d-weis-p-grohn-m-evers-m-thommes-r-e-garcia-s-antonyuk-implementation-of-formation-mechanisms-in-dem-simulation-of-the-spheronization-process-of-pharmaceutical-pellets-powder-technolog\/","url_meta":{"origin":504,"position":1},"title":"D. Weis, P. Grohn, M. Evers, M. Thommes, R.E. Garc\u00eda, S. Antonyuk “Implementation of formation mechanisms in DEM simulation of the spheronization process of pharmaceutical pellets.” Powder Technology 378: 667\u2013679, (2021).","date":"10\/17\/2020","format":false,"excerpt":"D. Weis, P. Grohn, M. Evers, M. Thommes, R.E. Garc\u00eda, S. Antonyuk \"Implementation of formation mechanisms in DEM simulation of the spheronization process of pharmaceutical pellets.\" Powder Technology 378: 667\u2013679, (2021).\u00a0https:\/\/doi.org\/10.1016\/j.powtec.2020.09.013 Abstract In the production process of pharmaceutical pellets with a narrow size distribution and a high sphericity, a combined\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":513,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/11\/04\/r-garcia-garcia-re-garcia-microstructural-effects-on-the-average-properties-in-porous-battery-electrodes-journal-of-power-sources-30911-19-2016\/","url_meta":{"origin":504,"position":2},"title":"R Garc\u00eda-Garc\u00eda, RE Garc\u00eda “Microstructural effects on the average properties in porous battery electrodes.”\u00a0Journal of Power Sources, 309:11-19, 2016.","date":"11\/04\/2017","format":false,"excerpt":"R Garc\u00eda-Garc\u00eda, RE Garc\u00eda \"Microstructural effects on the average properties in porous battery electrodes.\"\u00a0Journal of Power Sources, 309:11-19, 2016. Abstract A theoretical framework is formulated to analytically quantify the effects of the microstructure on the average properties of porous electrodes, including reactive area density and the through-thickness tortuosity as observed\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":496,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/11\/04\/dr-ely-re-garcia-m-thommes-ostwald-freundlich-diffusion-limited-dissolution-kinetics-of-nanoparticles-powder-technology-257120-123-2014\/","url_meta":{"origin":504,"position":3},"title":"DR Ely, RE Garc\u00eda, M Thommes “Ostwald\u2013Freundlich diffusion-limited dissolution kinetics of nanoparticles.”\u00a0Powder Technology, 257:120-123, 2014.","date":"11\/04\/2017","format":false,"excerpt":"DR Ely, RE Garc\u00eda, M Thommes \"Ostwald\u2013Freundlich diffusion-limited dissolution kinetics of nanoparticles.\"\u00a0Powder Technology, 257:120-123, 2014. Abstract For many years, nanoparticles have garnered increasing interest in pharmaceutical investigations. It is well known that the solubility of nanoparticles increases with decreasing size due to the Gibbs\u2013Thomson effect. However, there are currently no\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":381,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/10\/31\/the-effect-of-microstructure-on-the-galvanostatic-discharge-of-graphite-anode-electrodes-in-licoo2-based-rocking-chair-rechargeable-batteries\/","url_meta":{"origin":504,"position":4},"title":"M. Smith, RE Garc\u00eda, QC Horn “The Effect of Microstructure on the Galvanostatic Discharge of Graphite Anode Electrodes in LiCoO2-Based Rocking-Chair Rechargeable Batteries.”\u00a0Journal of the Electrochemical Society. 156:A896, 2009.","date":"10\/31\/2017","format":false,"excerpt":"M. Smith, RE Garc\u00eda, QC Horn \"The Effect of Microstructure on the Galvanostatic Discharge of Graphite Anode Electrodes in LiCoO2-Based Rocking-Chair Rechargeable Batteries.\"\u00a0Journal of the Electrochemical Society. 156:A896, 2009. Abstract By starting from experimentally determined cross sections of rechargeable lithium-ion batteries, the effect of microstructure on the galvanostatic discharge of\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":494,"url":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/2017\/11\/04\/m-ebner-d%e2%80%90w-chung-re-garcia-v-wood-tortuosity-anisotropy-in-lithium%e2%80%90ion-battery-electrodes-advanced-energy-materials-451301278-2014\/","url_meta":{"origin":504,"position":5},"title":"M Ebner, D\u2010W Chung, RE Garc\u00eda, V Wood “Tortuosity Anisotropy in Lithium\u2010Ion Battery Electrodes.”\u00a0Advanced Energy Materials, 4(5):1301278, 2014.","date":"11\/04\/2017","format":false,"excerpt":"M Ebner, D\u2010W Chung, RE Garc\u00eda, V Wood \"Tortuosity Anisotropy in Lithium\u2010Ion Battery Electrodes.\"\u00a0Advanced Energy Materials, 4(5):1301278, 2014. Abstract A systematic experimental study of lithium-ion battery porous electrode microstructures using synchrotron X-ray tomographic microscopy finds particle shape and fabrication-induced alignment to cause tortuosity anisotropy, which can impact battery performance. Tortuosity\u2026","rel":"","context":"In "Papers"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/posts\/504"}],"collection":[{"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/comments?post=504"}],"version-history":[{"count":2,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/posts\/504\/revisions"}],"predecessor-version":[{"id":506,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/posts\/504\/revisions\/506"}],"wp:attachment":[{"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/media?parent=504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/categories?post=504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/engineering.purdue.edu\/ComputationalMaterials\/index.php\/wp-json\/wp\/v2\/tags?post=504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}