Lynne Taylor

Professor of Industrial and Physical Pharmacy
Professor of Chemical Engineering (by courtesy)

Purdue University
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
(765) 496-6614 (office)
(765) 494-0805 (fax)
Bachelor of Pharmacy University of Bath, UK, 1990
Ph.D. in Pharmaceutical Technology University of Bradford, UK, 1996

Research Interests

The Taylor group is interested in exploring the fundamental science underlying the preformulation, formulation and manufacturing of drugs and drug/nutraceutical/food products. We collaborate with other academic groups as well as scientists working in industry. Our research has been funded by the National Science Foundation, the United States Department of Agriculture, and a variety of pharmaceutical companies. Our goal is to attain an improved molecular level understanding of pharmaceutical materials and formulations through the use of high resolution analytical techniques. Of particular interest are water-solid interactions and disordered systems, especially amorphous solid dispersions. Vibrational spectroscopic methods, in conjunction with other techniques such as X-ray diffraction and calorimetry, are used to provide information about the physical state of the solid e.g. crystalline or amorphous, the response of the material to changes in temperature and relative humidity and the nature of drug-drug, drug-excipient and drug-water interactions.

Awards and Honors

University Faculty Scholar 2009-2014
Entrepreneurial Leadership Academy Fellow 2008-2009
AAPS Outstanding Manuscript in Pharmaceutical Analysis and Quality 2008
AstraZeneca Innovation Award 2002
Purdue Seed for Success Award 2003, 2006
AACP New Investigator Grant 2003
AAPS New Investigator Award 2003

Selected Publications

Marsac, P.J., Rumondor, A.C.F., Nivens, D. E., Kestur, U. S.; Stanciu, L. and Taylor, L. S. (2010) Effect of Temperature and Moisture on the Miscibility of Amorphous Dispersions of Felodipine and Poly(vinylpyrrolidone). Journal of Pharmaceutical Sciences. 99(1):169-185.

Baird, J., Olayo-Valles, R., Rinaldi, C. and Taylor, L. S. (2010) Effect of Molecular Weight, Temperature, and Additives on the Moisture Sorption Properties of Polyethylene Glycol.Journal of Pharmaceutical Sciences. 9(1):154-168.

Rumondor, A.C.F., Stanford, L. A. and Taylor, L.S. (2009) Effect of Polymer Type and Storage Relative Humidity on the Kinetics of Felodipine Crystallization from Amorphous Solid Dispersions. Pharm. Res. 26 (12):2599-2606.

Rumondor, A.C.F., Ivanisevic, I., Bates, S., Alonzo, D. E. and Taylor, L. S. (2009) Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems. Pharm. Res. 26 (11):2523-2534.

Rumondor, A.C.F., Marsac, P.J., Stanford, L. A., and Taylor, L. S. (2009) Phase Behavior of oly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture. Molecular Pharmaceutics. 6 (5):1492-1505.

Guerrieri, P., and Taylor, L.S. (2009) Role of salt and excipient properties on disproportionation in the solid-state. Pharmaceutical Research 26(8):2015-2026.

Ortiz, J., Kestur U., Taylor, L.S. and Mauer, L.J. (2009) Interaction of environmental moisture with powdered green tea formulations: Relationship between catechin stability and moisture-induced phase transformations. Journal of Agricultural and Food Chemistry. 57(11):4691-4697.

Gift, A.D., Luner, P.E., Luedeman, L., and Taylor, L.S. (2009). Manipulating hydrate formation during high shear wet granulation using polymeric excipients. Journal of Pharmaceutical Sciences. 98(12):4670-4683.