Hsien-Hsin Tung

Adjunct Professor of Chemical Engineering
Volwiler Research Fellow, Abbvie

FRNY 1060
Purdue University
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
(765) 494-0050 (office)
(765) 494-0805 (fax)

Research Interests

1. Pharmaceutical crystallization – polymorphs, particle size and morphology modification, and scale-up
2. Partial engineering for enabling formulation such as solid dispersion, nanoparticles, pulmonary particles, and lyposomes
3. QbD-based process development and PAT applications in drug substance and drug product areas

Selected Publications

"Industrial Perspectives of Pharmaceutical Crystallization," H.-H. Tung, Organic Process R&D, 17(3), 445-454, (2013).

"Screening Crystal Morphologies from Crystal Structure," M. Singh, P. Verma, H.-H. Tung, S. Bordawekar and D. Ramkrishna, Cryst. Growth Des., 13(4), 1390-1396, (2013).

"Image-Analysis-Based Method for 3D Crystal Morphology Measurement and Polymorph Identification Using Confoccal Microscopy," M. Singh, J. Chakraborty, N. Nere, H.-H. Tung, S. Bordawekar, and D. Ramkrishna, Cryst. Growth Des., 12, 3735-3748, (2012).

"Formulation and Stability of Itraconzaole and Odanacatib Nanoparticles: Governing Physical Parameters," K. Varun, L. Wang, M. Riebe, H.-H. Tung and R. Prud'homme, Mol. Pharmaceutics., 6(4), 1118-1124, (2009)

Books

Crystallization of Organic Compounds, An Industrial Perspective, H.-H. Tung, E. Paul, M. Midler, J. McCauley, John Wiley & Sons (2009)

Patents

-"Nanoparticle Formation via Rapid Precipitation", US 20110053927, WO2009/131930
-"Potassium Salt on an HIV Integrase Inhibitor", US 7754731 (2010), CA 2588398 (2011), EP1819683
-"Formulations of Suberolyanilide Hydroxamic Acid and Methods for Producing the same", US 20100113829, US 20100112046
-"Method of Generating Amorphous Solids for Water-Insoluble Pharmaceuticals", US 20090111997, WO2007/061849
-"Process and Apparatus for the Production of Crystalline Organic Microparticle Compositions by Micro-milling and Crystallization on Micro-Seed and Their Use", US 20090087492, EP1993513, WO/2007/106768