James D. Litster
Professor of Chemical Engineering
Professor of Industrial and Physical Pharmacy
School of Chemical Engineering
Forney Hall of Chemical Engineering
480 Stadium Mall Drive
West Lafayette, IN 47907-2100
My research interests are in the area of Particle Technology, particularly particle design and formulation. Particle design is the production of novel particles with specific attributes. These attributes are controlled by the size, morphology and surface properties of the particles that are produced. To control these attributes, both the particle formation processes and the feed formulation properties need to be controlled. The products of interest are many and varied, including proteins and other biological materials, pharmaceuticals, detergents and consumer goods, food, ceramics and high value materials, fertilizers and agricultural chemicals, and minerals.
My major research area is granulation and agglomeration. The research is targeted at several levels:
- Particle level - Prediction of the behaviour of partially saturated bulk powders and granules from understanding of the particle-particle and particle-binder interactions in the granule;
- Rate process level - Mapping of regimes of operation for the key rate processes in granulation - wetting and nucleation, growth and consolidation, breakage and attrition and the development of mathematical models for these processes.
- Unit operation and granulation circuit level - Development of scale-up rules for granulation processes. This includes simulation, optimization and control of continuous granulation circuits.
- Multiscale modeling of granulation processes;
- Regime mapping and quantitative modeling of wet granule breakage in granulators;
- Characterization of cohesive powder flows in a mixer granulator;
- Design of regime separated granulators for continuous granulation.;
- Fundamental studies of the secondary nucleation of proteins;
- Crystallization of proteins from protein mixtures;
- Microfluidic crystallization for particle design;
- Precipitation and liquid-liquid separation of soy proteins.
- Kaoutar Abbou Oucherif
- Nathan B. Davis
- Nathan J. Davis
- Jennifer Lu
- Daniel Pohlman
- Ridade Sayin
Awards and Honors
Litster, JD, and Ennis, BJ, (2004). The Science and Engineering of Granulation Processes, Kluwer Powder Technology Series, B. Scarlett (ed.).
Hapgood, K.,, Iveson, SM, Litster, JD, and Liu, L.X., (2008). Chapter 20 Granulation Rate Processes in Handbook of Powder Technology v.11 Granulation, Salman, A.J., Hounslow, M.J. and Seville, J.P.K (eds), Elsevier
He, Y, Liu, LX and Litster JD, (2009). Chapter 16 Scale-up Consideration in Granulation, In Handbook of Pharmaceutical Granulation Technology (3rd Edition, D.M. Parikh Ed.),. Marcel Dekker, Inc., New York.
Snow, RH, Allen, T, Ennis, B.J. and Litster, JD, (2009). Section 20 Size Reduction and Size Enlargement In Perrys Ch'emical Engineers Handbook, D. Green (ed.), MacGraw-Hill, (98pp).
“Experimental Validation of a 2-D Population Balance Model for Spray Coating Processes,” J. Li, B. Freireich, C. Wassgren, and J. D. Litster, Chem Eng Sci, DOI: 10.1016/j.ces.2012.02.036 (2012)
“Growth Rates of Ibuprofen Crystals Grown From Ethanol and Aqueous Ethanol,” A. Rashid, E. T. White, T. Howes, J. D. Litster, and I. Marziano, Chemical Engineering R&D, 90, 158-161 (2012)
“Examining the failure modes of wet granular materials using dynamic diametrical compression,” R. M. Smith, and J. D. Litster, Powder Technology, in press (2012)
“Crystallization Kinetics of Ibuprofen from Ethanol and Aqueous Ethanol,” A. Rashid, E. T. White, T. Howes, J. D. Litster, and I. Marziano, Chemical Engineering Transactions, 24, 631-636 (2011)
“Granule Formation Mechanisms and Morphology from Single Drop Impact on Powder Beds,” H. Emady, D. Kayrak-Talay, W. Schwerin, and J. D. Litster, Powder Technology, 212(1), 69-79 (2011)
"A priori Performance Prediction in Pharmaceutical Wet Granulation: Testing the Applicability of the Nucleation Regime Map to a Formulation with a Broad Size Distribution and Dry Binder Addition,” D. Kayrak-Talay, and J. D. Litster, International Journal of Pharmaceutics, 418, 254-264 (2011)
“A Compartmental Approach to Studying Particle Motion in Mixers Using Discrete Element Modeling,” B. Freireich, J. Li, J. D. Litster, Wassgren, Chemical Engineering Science, 66(16), 3592-3604 (2011)
“Correlation of Second Virial Coefficient with Solubility for Proteins in Salt Solutions,” C. M. Mehta, E. T. White, and J. D. Litster, Biotechnology Progress, on line, DOI 10.1002/btpr.724 (2011)
“Modeling the Powder Roll Compaction Process: Comparison of 2-D Finite Element Method and the Rolling Theory for Granular Solids (Johanson's model),” A. R. Muliadi, J. D. Litster, and C. R. Wassgren, Powder Technology, on line, DOI: 10.1016/j.powtec.2011.12.001 (2011)
“A General Compartment-Based Population Balance Model for Particle Coating and Layered Granulation,” J. Li, B. Freireich, C. Wassgren, and J. D. Litster, AIChE J, DOI: 10.1002/aic.12678 (2011)