Center for
Implantable Devices

A Purdue College of Engineering Preeminent Team

Innovating New Implantable Device Technologies

Research

Epilepsy

  • Closed-loop epilepsy prostheses
  • Nanowatt on-chip seizure detection
  • Real-time closed loop seizure prediction
  • Charge-balanced cortical stimulating circuits

Glaucoma

  • Continuous intra-ocular pressure (IOP) monitoring
  • Mixed-signal integrated circuits
  • Extreme miniaturization

Cardiology

  • Minimally invasive active devices for intracardiac monitoring
  • High data-rate telemetry from within the heart
  • Chronic blood glucose monitoring

Neural Interfaces

  • Networked, magnetically inserted, stimulating and recording electrodes
  • Injectable EMG sensing from reinnervated muscle for prosthesis control
  • Implantable LED optrodres for stimulating rhodopsin expressing neurons

People

  • Hyowon (Hugh) Lee - Preeminent Team Leader
    Associate Professor of Biomedical Engineering
      Office: MJIS 2070   Lab: MJIS 2058B
  • Ashraf Alam
    Jai N. Gupta Professor of Electrical and Computer Engineering
      WANG 3051
  • Ed Bartlett
    Associate Professor, Biology and Weldon School of Biomedical Engineering
  • Amy Brewster
    Assistant Professor, Psychology and Weldon School of Biomedical Engineering
  • Zhihong Chen
    Associate Professor of Electrical and Computer Engineering
      BRK 1299
  • Tim Fisher
    Associate Professor of Electrical and Computer Engineering
      BRK 2027A
  • John Jefferys
    Adjunct Professor, Weldon School of Biomedical Engineering
    Professor, Neuroscience, Oxford University, UK
  • Chi Hwan Lee
    Assistant Professor of Biomedical Engineering
      MJIS 2086
  • Hugh Lee
    Assistant Professor of Biomedical Engineering
      MJIS 2082
  • Zhongming Liu
    Assistant Professor of Electrical and Computer Engineering and Biomedical Engineering
      MJIS 2021
  • Thelma Lovick
    Adjunct Professor, Weldon School of Biomedical Engineering
    Honorary Reader, Physiology, University of Bristol, UK
  • Mark Lundstrom
    Don and Carol Scifres Distinguished Professor of Electrical and Computer Engineering
      WANG 3055
  • Ramses Martinez
    Assistant Professor - Joint Appointment with Biomedical Engineering
      MJIS 2033
  • Anand Raghunathan
    Professor of Electrical and Computer Engineering
      MSEE 348
  • Vijay Raghunathan
    Associate Professor of Electrical and Computer Engineering
      MSEE 224
  • Jenna Rickus
    Professor of Agriculture and Biological, Biomedical Engineering
      MJIS 2029
  • Kaushik Roy
    Edward G. Tiedemann Jr. Distinguished Professor of Electrical and Computer Engineering
      MJIS 232
  • Mark Sayles
    Assistant Professor of Biomedical Engineering and Speech, Language & Hearing Sciences
      MJIS 232
  • Gabriel Simon
    Adjunct Professor, Weldon School of Biomedical Engineering
    Director, Instituto Oftalmologia Gabriel Simon, Spain

Projects

Dynamic Impedance Matching in Wireless Power Transfer Systems »

This project is motivated by the potential to enable a new generation of miniature, fully-implantable medical devices with wireless power transfer (WPT) technology with autonomous impedance matching capabilities.

Insertion Systems for Ultra-Thin Neural Electrodes »

The ability to treat neurological diseases using electrodes inserted into the brain with minimal negative physical consequence motivates this research.

Inherently Passive, Wirelessly Driven Stimulating Electrodes »

The possibility of minimizing the physical size of electrical stimulation systems and improving therapies that restore physiological functions to improve patient quality of life motivates this research on applying the theory of electromagnetics to developing improved electrical stimulation systems.

Effect of Electrical Stimulation on Vagal Nerve Conduction in Patients with Gastroparesis »

This research targets the development of improved therapy for gastroparesis, a relatively rare disease mostly affecting Type I diabetic patients that can induce strong feelings of isolation and depression without effective treatment.

Implantable Ultra-Miniature Intra-Ocular Pressure Sensor »

This project is motivated by the potential benefits of continuous monitoring of the conditions inside the human eye for improved treatments of glaucoma.

Autonomic Dysfunction in Experimental Epilepsy: Potential Mechanisms for SUDEP »

The possibility of reducing the number of deaths attributed to SUDEP by the reduction of seizure magnitude and frequency motivates this research.

Long-Term in-Vivo Monitoring of Neuromuscular Performance in Mice »

The possibility of improving the quality of life of people living with neuromuscular disease motivates this study to develop a closed-loop electrical stimulation therapy delivery system.

Sub-Threshold Neural Processing Algorithms in Silicon »

The innumerable benefits of an improved understanding of the human nervous system motivates this research for developing improved technology for hardware critical to bioelectric signal recording and stimulation.

Suppressing Inflammation via Neuromodulation of the Gastrointestinal Tract »

The possibility of reducing undesirable inflammatory responses in humans by electrical stimulation of the peripheral nervous system motivates this research.

Publications

In press – K. Qing, M. P. Ward, P. P. Irazoqui, "An Ultra Low Power, RF Energy Harvesting Transceiver for Multiple Node Sensor Application, IEEE Transactions on Circuits and Systems II, 2015.

In press – K. Qing, M. P. Ward, P. P. Irazoqui, "Burst-Modulated Waveforms Optimize Electrical Stimuli for Charge Efficiency and Fiber Selectivity, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2015.

In press – I. Dryg, K. Qing, M. P. Ward, H. Mei, J. Schaffer, P. P. Irazoqui, "Magnetically Inserted Neural Electrodes: Tissue Response and Functional Lifetime, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2015.

In press – O. Gall, H. Mei, C. Meng, H. Bhamra, S. W. M. John, P. P. Irazoqui, "Power Management of Real-Time Subcutaneous Implantable Pressure Sensing Systems, IEEE Transactions on Biomedical Circuits and Systems, 2015.

In press - S. T. Lee, P. Williams, C. Braine, S. W. M. John, P. P. Irazoqui, "A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2015.

In press – V. Nagaraj, S. T. Lee, E. Krook-Magnuson, I. Soltesz, P. Benquet, P. P. Irazoqui, T. Netoff, "Future of Seizure Prediction and Intervention: Closing the Loop, Journal of Clinical Neurophysiology, 2015.

J. Maeng, C. Meng, P. P. Irazoqui, "Wafer-Scale Integrated Micro-Supercapacitors On An Ultrathin And Highly Flexible Biomedical Platform, Biomedical Microdevices, Vol 17, No 1, Feb. 2015.

G. Xiong, C. Meng, R.G. Reifenberger, P. P. Irazoqui, and T.S. Fisher,"Graphitic Petal Micro-Supercapacitor Electrodes for Ultra-High Power Density, Energy Technology, Vol 2, pp. 897-905: Nov 2014. DOI: 10.1002/ente.201402055

H. Mei, P. P. Irazoqui, "Wireless Power Transfer to Medical Implants, Nature Biotechnology – News & Views, No. 32, pp. 1008-1010, Oct. 2014.

H. Markandeya, P.P. Irazoqui, Kaushik Roy, "Low energy two-stage algorithm for high efficacy epileptic seizure detection, IEEE Transactions on Very Large Scale Integration Systems, Online: Feb. 2014. DOI: 10.1109/TVLSI.2014.2302798

M. Ward, K. Qing, K. Otto, R. Worth, S. John, and P.P. Irazoqui,"A Flexible Platform for Biofeedback-driven Control and Personalization of Electrical Nerve Stimulation Therapy, IEEE Transactions on Neural Systems and Rehabilitation Engineering, Online: Jul., 2014. DOI: 10.1109/TNSRE.2014.2351271

J. Lynch, P. P. Irazoqui,A Low Power Logic-Compatible Multi-bit Memory Bit Cell Architecture with Differential Pair and Current Stop Constructs, IEEE Tran. on Circuits and Systems I, Online: Jul 2014. DOI: 10.1109/TCSI.2014.2334791

G. Xiong, C. Meng, R.G. Reifenberger, P.P. Irazoqui, and T.S. Fisher,"Graphitic petal electrodes for all-solid-state flexible supercapacitors, Advanced Energy Materials, vol. 4, no. 3, Feb. 2014.

E. J. Juan, R. Gonzalez, G. Albors, M. P. Ward, P. P. Irazoqui, "Vagus Nerve Modulation Using Focused Pulsed Ultrasound: Potential Applications and Preliminary Observations in a Rat International Journal of Imaging Systems and Technology, vol. 14, no. 1, pp. 67-71, 2014.

J. A. Wilden, K. Y. Qing, S. Hauser, W. J. McBride, P. P. Irazoqui, Z. A. Rodd, "Altering Neuronal Activity of the Nucleus Accumbens Shell by Pharmacological Silencing and Deep Brain Stimulation Reduces Oral Ethanol Consumption in Alcohol-Preferring (P) Rats. Journal of Neurosurgery Jan. 2013.

C. Meng, J. Maeng, S. W. M. John, and P.P. Irazoqui, "Ultrasmall integrated 3D micro-supercapacitors solve energy storage on miniature devices, Advanced Energy Materials, Dec. 2013.

G. Xiong, C. Meng, R.G. Reifenberger, P.P. Irazoqui, and T.S. Fisher, "A review of graphene-based electrochemical micro-supercapacitors, Electroanalysis Nov. 2013.

C. Meng, O. Z. Gall, and P. P. Irazoqui, "A flexible super-capacitive solid-state power supply for miniature implantable medical devices, Biomedical Microdevices 2013.

R. Bercich, D. R. Duffy, P. P. Irazoqui, "Far Field RF Powering of Implantable Devices: Safety Considerations, IEEE Transactions on Biomedical Engineering, Vol. 60, No. 8, pp. 2107-2112, Aug. 2013.

E. Y. Chow, M. M. Morris, P. P. Irazoqui, "Implantable RF Medical Devices, IEEE Microwave Magazine, Vol. 14, No. 4, pp. 64-73, May 2013.

A.L. Chlebowski, E.Y. Chow, C. Ellison, P.P. Irazoqui, "Integrated LTCC Packaging for Use in Biomedical Devices, Bio-Medical Materials and Engineering, Vol. 22, No. 6, pp. 361-372, Jan. 2012.

A. W. Conovaloff, B. L. Beier, P. P. Irazoqui, A. Panitch, "Effects of a synthetic bioactive peptide on neurite growth and nerve growth factor release in chondroitin sulfate hydrogels, Biomatter, Vol. 1, No. 2, 2012.

S. Raghunathan, A. Jaitli, P.P. Irazoqui, "Multi-Stage Seizure Detection Techniques Optimized for Low-Power Hardware Platforms, Epilepsy & Behavior, Vol. 22, pp. S61-S68, Dec. 2011.

D. Ha, W.N. de Vries, S.W. John, P.P. Irazoqui, W.J. Chappell, "Polymer-Based Miniature Flexible Capacitive Pressure Sensor for Intraocular Pressure (IOP) Monitoring Inside a Mouse Eye, Biomedical Microdevices, Published online, Oct. 2011.

E.Y. Chow, C.L. Yang, A. Chlebowski, S. Moon, P.P. Irazoqui, W.J. Chappell, "RF Powering for Miniature Implantable Biomedical Devices, Institute of Electronics and Electrical Engineers Transactions on Antennas & Propagations, Vol. 59, No. 6, pp. 2379-2387, Jun. 2011.

S. Raghunathan, S. Gupta, H. Markandeya, P.P. Irazoqui, Kaushik Roy, "Ultra Low-Power Algorithm Design for Implantable Devices: Application to Epilepsy Prostheses, Journal of Low Power Electronics and Applications,  Vol. 1, pp. 175-203, May 2011.

P. Rajdev, M.P. Ward, and P.P. Irazoqui, "Effect of Stimulus Parameters in the Treatment of Seizures by Electrical Stimulation in the Kainate Animal Model, International Journal of Neural Systems, Vol. 21, No. 2, pp. 151–162, Apr. 2011.

M.S. Graves, T. Hassell, B.L. Beier, G.O. Albors, and P.P. Irazoqui, "Electrically Mediated Neuronal Guidance with Applied Alternating Current Electric Fields, Annals of Biomedical Engineering, Vol. 39, No. 2, pp. 1759-1767, Feb. 2011.

E.Y. Chow, A. Chlebowski, P.P. Irazoqui, "A Miniature Implantable RF-Wireless Active Glaucoma Intraocular Pressure Monitor, Institute of Electronics and Electrical Engineers Transactions on Biomedical Circuits and Systems, Vol. 4, No. 6, pp. 340-349, Dec. 2010.

B.L. Beier, K.M. Musick, A. Matsumoto, A. Panitch, E.A. Nauman, and P.P. Irazoqui, "Toward a Continuous Intravascular Glucose Monitoring System, Sensors, Special Issue on Biodevices and Materials, Vol. 11, pp. 409-424, Dec. 2010.

A.R. Kahn, E.Y. Chow, O. Abdel-Latief, P.P. Irazoqui, "Low-Power, High Data Rate Transceiver System for Implantable Prostheses, International Journal of Telemedicine and Applications, Vol. 2010, Nov. 2010.

K.M. Musick, A.C. Coffey, and P.P. Irazoqui, "Sensor to Detect Endothelialization on an Active Coronary Stent, BioMedical Engineering OnLine, Vol. 9, No. 67, Nov. 2010.

S. Raghunathan, S.K. Gupta, H. Markandeya, K. Roy and P.P. Irazoqui, "A Critical Comparison of Seizure Detection Features for an Implantable Epilepsy Prosthesis, Journal of Neuroscience Methods, Vol. 193, pp. 106-117, 2010.

E.Y. Chow, A. Chlebowski, S. Chakraborty, W.J. Chappell, and P.P. Irazoqui, "Fully Wireless Implantable Cardiovascular Pressure Monitor Integrated with a Medical Stent, Institute of Electronics and Electrical Engineers Transactions on Biomedical Engineering, Vol. 57, No. 6, pp. 1487-1496, Jun. 2010.

M.P. Ward and P.P. Irazoqui, "Evolving Refractory Major Depressive Disorder Diagnostic and Treatment Paradigms: Toward Closed-Loop Therapeutics, Frontiers in Neuroengineering, Vol. 3, May 2010.

P. Rajdev, M.P. Ward, R.M. Worth, J.L. Rickus, and P.P. Irazoqui, "Real-Time Seizure Prediction from Local Field Potentials using an Adaptive Wiener Algorithm, Computers in Biology and Medicine, Vol. 40, No. 1, pp. 97-108, Jan. 2010.

E.Y. Chow, Y. Ouyang, B. Beier, P.P. Irazoqui, W.J. Chappell, "Evaluation of Cardiovascular Stents as Antennas for Implantable Wireless Applications, Institute of Electronics and Electrical Engineers Transactions on Microwave Theory and Techniques, Vol. 57, No. 10, pp. 2523-2532, Oct. 2009.

D.B. Jaroch, M.P. Ward, E.Y. Chow, J.L. Rickus, P.P. Irazoqui, "Magnetic Insertion System for Flexible Electrode Implantation, Journal of Neuroscience Methods, Vol. 183, No. 2, pp. 213-222, Oct. 2009.

E.Y. Chow, B. Beier, W.J. Chappell, P.P. Irazoqui, "Towards an Implantable Wireless Cardiac Monitoring Platform Integrated With an FDA Approved Cardiovascular Stent, Journal of Interventional Cardiology, Vol. 22, No. 5, pp. 479-487, Oct. 2009.

S.C. Schachter, J. Guttag, S. Schiff, D.L. Schomer, P.P. Irazoqui, et al., "Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit, Epilepsy & Behavior, Vol. 16, No. 1, pp. 3-46, Sep. 2009.

S. Raghunathan, S.K. Gupta, M.P. Ward, R.M. Worth, K. Roy, P.P. Irazoqui, "The Design and Hardware Implementation of a Low-Power Real-Time Seizure Detection Algorithm, Journal of Neural Engineering, Vol. 6, p. 056005, Aug. 2009.

M.P. Ward, P. Rajdev, C. Ellison, P.P. Irazoqui, "Toward a Comparison of Microelectrodes for Acute and Chronic Recordings, Brain Research, Vol. 1282, pp. 183-200, Jul. 2009.

S.S. Jedlicka, M. Dadarlat, T. Hassell, Y. Lin, A. Young, M. Zhang, P.P. Irazoqui, J.L. Rickus, "Calibration of Neurotransmitter Release from Neural Cells for Therapeutic Implants, International Journal of Neural Systems, Vol. 19, No. 3, pp. 197-212, Jun. 2009.

E.Y. Chow, C.L. Yang, A. Chlebowski, S. Moon, W.J. Chappell, P.P. Irazoqui, "Implantable Wireless Telemetry Boards for in-vivo Transocular Transmission, Institute of Electrical and Electronics Engineers Transactions on Microwave Theory & Techniques, Vol. 56, No. 12, pp. 3200-3208, Dec. 2008.

M. Rokkam, M.R. Chatni, A. ul Haque, A.R. DeCarlo, B.F. Robinson, P.P. Irazoqui, D.M. Porterfield, "High-Density Data Acquisition System and Signal Preprocessor for Interfacing with Microelectromechanical System-Based Biosensor Arrays, Review of Scientific Instruments, No. 78, pp. 44303-44312, Apr. 2007.

A. ul Haque, M. Rokkam, A.R. DeCarlo, S.T. Wereley, H.W. Wells, W.T. McLamb, S.J. Roux, P.P. Irazoqui, D.M. Porterfield, "A MEMS Fabricated Cell Electrophysiology Laboratory Biochip for In-silico Calcium Measurements, Sensors and Actuators, Vol. 123, pp. 391-399, 2007.

A. ul Haque, A.R. DeCarlo, M. Rokkam, S.T. Wereley, P.P. Irazoqui, H.W. Wells, W.T. McLamb, S.J. Roux, D.M. Porterfield, "Design, Fabrication and Characterization of an In Silico Cell Physiology Lab for Bio Sensing Applications, Journal of Physics Conference Series, Vol. 34, pp. 740-746, 2006.

P.P. Irazoqui, I. Mody, J.W. Judy, "Inductive Powering in Miniature Implantable Neural Recording Devices, IEEE EMBS Magazine, pp. 48-54, Dec. 2005.

Contact

  • Center for Implantable Devices
  • Dr. Hyowon (Hugh) Lee
  • 206 S. Martin Jischke Dr.
  • MJIS 2070 (Office)
  • MJIS 2058B (Lab)
  • West Lafayette, IN 47907