Educational Qualification

Professor: 2000 - date, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Visiting Scholar: 2008, Genomics Research Center, Academic Sinica
              2012, Weldon School of Biomedical Engineering, Purdue University,
Associate Professor: 1994-2000, Chung Hwa University of Medical Technology, Tainan, Taiwan
Ph.D (Chemistry): 1990-1994, Taiwan University, Taipei, Taiwan.
M.Sc (Chemistry): 1988-1990, Taiwan University, Taipei, Taiwan.
B.Sc (Chemistry): 1981-1985, Chung-Yuan Christian University, Chung Li, Taiwan.

Research Project:
1. Hyphenated Technology in Natural Product.
2. Structure Elucidation
3. Cosmetic ingredient Developed

HighLights
­ Isolated various classes of bioactive natural products from Plant using wide variety of chromatographic techniques and characterized them by using extensive study of their spectral data.
­ Expertise in using various chromatographic methods like column chromatography using silica gel, sephdex LH-20, HP-20 resin, reversed phase column chromatography and thin layer chromatography.
­ Expertise in handling the instruments like NMR, LC-MS, GC-MS, FT-IR, UV-VIS, and HPLC.
­ Expertise in analyzing the spectroscopic data like IR, UV, Mass, 1D-NMR (1H, 13C,DEPT) and 2D-NMR (COSY, TOCSY, NOESY, HSQC and HMBC) for the structural determination of natural products.

Recent Research Publications

• Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography–tandem mass spectrometry. Wang KC, Cheng MC, Hsieh CL, Hsu JF, Wu JD, Lee CK*. Forensic Science International. 2013, 224(1-3):84-89.

• Natural Product Development and Application in Taiwan. Lee, Ching-Kuo. Huaxue 2013, 71(1):57-66.

• Heptadecanols from the leaves of Persea americana var. americanaLee, Tzong-Huei; Tsai, Yow-Fu; Huang, Tzu-Tien; Chen, Pi-Yu; Liang, Wen-Li; Lee, Ching-Kuo, From Food Chemistry (2012), 132(2), 921-9244.

• Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana Hayata Yu, Chia-Chun; Hsieh, Ching-Ruey; Hsiao, George; Chen, Pi-Yu; Chang, Meng-Lun; Yin, Hwa-Wen; Lee, Tzong-Huei; Lee, Ching-Kuo, From Molecules (2012), 17, 2082-2090.
• Antimutagenic Constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with Potential Cancer Chemopreventive Activity Chen, Huang-Hui; Chiang, Wenchang; Chang, Jang-Yang; Chien, Ya-Lin; Lee, Ching-Kuo; Liu, Ko-Jiunn; Cheng, Yen-Ting; Chen, Ting-Fang; Kuo, Yueh-Hsiung; Kuo, Ching-Chuan From Journal of Agricultural and Food Chemistry (2011), 59(12), 6444-6452.
• Ficuschlorins A - D, Lactone Chlorins from the Leaves of Ficus microcarpa
  Lin Huan-You; Chiu, Hsi-Lin; Lan, Yu-Hsuang; Tzeng, Chih-Ying; Lee, Tzong-Huei; Lee, Ching-Kuo; Shao, Yi-Yuan; Chen, Chiy-Rong; Chang, Chi-I.; Kuo, Yueh-Hsiung, Chemistry & Biodiversity (2011), 8(9), 1701-1708.
• Ficusmicrochlorin A—C, Two New Methoxy Lactone Chlorins and an Anhydride Chlorin from the Leaves of Ficus microcarpa Lin, Huan-You; Chiu, Hsi-Lin; Lu, Te-Ling; Tzeng, Chih-Ying; Lee, Tzong-Huei; Lee, Ching-Kuo; Shao, Yi-Yuan; Chen, Chiy-Rong; Chang, Chi-I; Kuo, Yueh-Hsiung , Chem. Pharm. Bull. (2011), 59(1), 113-116.
• Cytotoxic steroidal saponins from Agave sisalana Chen, Pi-Yu; Chen, Chin-Hui; Kuo, Ching-Chuan; Lee, Tzong-Huei; Kuo, Yueh-Hsiung; Lee, Ching-Kuo, Planta Medica (2011), 77(9), 929-933.
• Rapid identification of the antioxidant constituent of Koelreuteria henryi Chen, Chin-Hui; Chen, Pi-Yu; Wang, Kuang-Chuan; Lee, Ching-Kuo, Journal of the Chinese Chemical Society (Taipei, Taiwan) (2010), 57(3A), 404-410.
• Constituents of Polyalthia longifolia var. pendula Lee, Tzong-Huei; Wang, Mei-Jhen; Chen, Pi-Yu; Wu, Tung-Ying; Wen, Wu-Che; Tsai, Fu-Yu; Lee, Ching-Kuo, Journal of Natural Products (2009), 72(11), 1960-1963. 
• Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase. Chen, Chin-Hui; Chan, Hsiu-Chen; Chu, Yi-Tsu; Ho, Hsin-Yi; Chen, Pi-Yu; Lee, Tzong-Huei; Lee, Ching-Kuo, Molecules (2009), 14(8), 2947-2958.
• A new flavonol galloylrhamnoside and a new lignan glucoside from the leaves of Koelreuteria henryi Dummer Lee, Tzong-Huei; Chiang, Yuan-Hsiang; Chen, Chin-Hui; Chen, Pi-Yu; Lee, Ching-Kuo, Journal of Natural Medicines (2009), 63(2), 209-214.
• Simultaneous detection and quantitation of highly water-soluble herbicides in serum using ion-pair liquid chromatography-tandem mass spectrometry Wang, Kuang-Chuan; Chen, Shih-Ming; Hsu, Jung-Fa; Cheng, Sheaw-Guey; Lee, Ching-Kuo, Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences (2008), 876(2), 211-218.
• nexpected novel pheophytin peroxides from the leaves of Bidens pilosa. Lee, Tzong-Huei; Lu, Chung-Kuang; Kuo, Yueh-Hsiung; Lo, Jir-Mehng; Lee, Ching-Kuo, Helvetica Chimica Acta (2008), 91(1), 79-84.