Dr. Chad Carroll

Areas of Research

Etiology and pathophysiology of tendinopathies

Projects

• Regulation of tendon properties by estrogenic compounds

• Role of advanced glycation in the development of diabetic tendinopathies

The long-term goal of my research is to contribute to the development of effective treatments for tendon pathology. Our work combines aspects of engineering, cell biology, molecular biology, and biochemistry to the study of tendon biology and pathophysiology. Tendon complaints are one of the most common musculoskeletal disorders. Painful tendinopathies reduce the quality of life of afflicted individuals and limit their ability to complete activities of daily living. Little in vivo data exist to aid in the treatment or prevention of painful tendinopathies. Our goal is to fill these knowledge gaps. Our laboratory uses human, rodent, and cell culture models to address our research goals in a bench-to-bedside manner. Methodologies utilized by our laboratory and collaborators include: mechanical testing of tendons in vivo and ex vivo using ultrasound, atomic force microscopy, mitochondrial respiration in tenocytes, RNA sequencing, and microdialysis in humans.

Recruitment Needs

Searching for one highly motivated PhD student with a strong interest in the area of tendon biology/pathophysiology who is interested in a combined engineering and biology experience.

Please feel free to contact Dr. Carroll directly.

Email: carrol71@purdue.edu