Dr. Douglas Brubaker

Areas of Research

Interrogation of host-microbiome interactions in inflammatory pathologies and cancers with the goal of developing new therapeutic strategies.


My lab is broadly interested in profiling and modeling the full complexity of interactions between microbial communities and host cell signaling biology. Our overall goal is to understand these interactions with sufficient mechanistic detail to predictably and therapeutically control them. To that end, we have projects available in a range of disease indications:

•Microbiome-mediated therapeutic resistance mechanisms to immune targeted therapies in inflammatory bowel diseases.
•Gut microbiome-immune-neurological interactions in neurodegenerative diseases.
•Longitudinal host and microbiome multi-omics in bacterial vaginosis patients.
•Microbiome regulation of tumor metastatic and quiescent behavior.
•Probiotic and prebiotic prevention or treatment of rheumatic and musculoskeletal diseases.

Our studies involve computational modeling of diverse data modalities (e.g. metagenomics, metabolomics, proteomics, transcriptomics) from patients, animal models, and cell culture systems followed by experimental interrogation of the key findings of these models.

Recruitment Needs

Looking for highly motivated students with interests in one or more project areas. 

Please feel free to contact Dr. Brubaker directly.

Email: dkbrubak@purdue.edu