Register here:  https://redcap.link/DRC-JeffreyPessin09.14.22

Abstract: The hepatic regulation of glucose and lipid metabolism occur in a zonation selective manner with hepatocytes in the periportal region displaying greater extents of gluconeogenesis and hepatocytes in the pericentral region displaying greater extents of de novo lipogenesis. Using single cell RNAseq coupled with single molecule fluorescence in situ hydridization, we will present data demonstrating that the zonation specificity of gluconeogenic gene expression is not fixed but can vary depending on physiologic conditions. More detailed transcriptional analyses further reveals that the transcriptional activation mechanism of gluconeogenic and lipogenic gene expression are distinct. The consequences of these findings with regard to metabolic dysregulation during insulin resistance will be discussed. 

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More information can be found here: https://www.vumc.org/diabetescenter/virtual-seminar-series