Diabetes Research Virtual Seminar Series - Wed., June 15 2:00 p.m.
| Event Date: | June 15, 2022 |
|---|---|
| Hosted By: | Indiana University Center for Diabetes and Metabolic Diseases |
| Time: | 2:00 p.m. |
| Location: | Virtual |
| Priority: | No |
| School or Program: | Non-Engineering |
| College Calendar: | Show |
Please register here: https://redcap.link/DRCSeminar-MaureenGannon6.15.22
The seminar is entitled "Intersection of prostaglandin E2 and GLP-1 signaling pathways to promote beta-cell identity, proliferation, and survival."
Abstract: Our group has found that modulation of prostaglandin E2 (PGE2) receptor signaling increases beta-cell proliferation, promotes beta-cell identity, and protects beta-cells from cytokines. Interestingly, GLP-1 receptor (GLP-1R) agonists lead to many of the same beneficial effects. Our data also suggest that Nrf2, a transcriptional regulator of antioxidant pathways, is activated by and necessary for the beneficial effects of manipulating PGE2 signaling. In collaboration with the Scott and Garcia-Ocana labs at Mt. Sinai we are exploring the relationship between PGE2, GLP-1R, and Nrf2 pathways in maintenance of functional beta-call mass and protection from oxidative stress.
The Diabetes Research Virtual Seminar Series is sponsored by the Indiana University School of Medicine Center for Diabetes and Metabolic Diseases. Questions, feedback, or suggestions for future speakers? Contact us at: virtual.seminar.series@vumc.org
2022-06-15 14:00:00 2022-06-15 15:00:00 America/Indiana/Indianapolis Diabetes Research Virtual Seminar Series - Wed., June 15 2:00 p.m. Dr. Maureen Gannon, Associate Dean for Faculty Development, Vanderbilt University Medical Center and Professor of Medicine, Molecular Physiology and Biophysics, and Cell and Developmental Biology will present the Diabetes Research Virtual Seminar on Wednesday, June 15th at 2:00 p.m. Virtual