BME Seminar Apr 24

Event Date: April 24, 2013
Time: 9:30 a.m.
Location: MJIS 1001, WL campus
"Strategies to Promote Mammalian Cell Functions Pertinent to New Tissue Formation for Biomedical Applications," presented by Rena Bizios, Ph.D., the Peter T. Flawn Professor , Department of Biomedical Engineering, The University of Texas at San Antonio.

Success of various implanted prosthetic devices as well as of current, and future, tissue engineering endeavors depends critically on the timely formation of new tissue with composition, structure, and function similar to that of the respective physiological prototypes.  The critical need for resolution of these important issues has motivated pursuit of novel directions and promotion of new trends in biomedical research.

Recognition of the importance of the events that take place at the tissue/implant material interfaces has promoted investigations of cellular- and molecular-level interactions, seeks to elucidate underlying mechanisms, and incorporates findings from advances in cellular and molecular biology, biochemistry, biomaterials, and cellular engineering in the design and formulation of the next generation of biomaterials. Examples of such endeavors include: modification of material surfaces with immobilized bioactive compounds (such as select adhesive peptides); micropatterning (in order to direct and control subsequent adhesion of specific cell types in designated domains of the substrate material surface); and novel material formulations (specifically, nanoceramics and nanocomposites) with unique biocompatibility and/or improved properties (such as mechanical and electrical ones). Cellular, in vitro models have been used to evaluate the cytocompatibility of these constructs and to determine the conditions (for example, chemical, mechanical and electrical stimuli) needed to promote cell functions pertinent to new tissue formation on such materials.

Undoubtedly, the effects of the substrates (on which anchorage-dependent cells adhere and function) as well as of pertinent biochemical and biophysical stimuli (which modulate the underlying cellular, molecular, and genetic events of biological tissues) play a crucial role in new tissue formation at respective tissue-biomaterial interfaces. These aspects need, therefore, to be elucidated and then appropriately applied, orchestrated, and optimized in order to achieve the objective of new tissue formation pertinent to various biomedical applications. To date, however, these aspects remain (at best) partially understood but are the subject of continuing, cutting-edge research. Biomaterials, which reliably and predictably promote specific interactions of biomolecules leading to targeted modulation and/or control of subsequent functions of select mammalian cells, have the potential of novel tissue-engineering, tissue-regeneration and biotechnology-related applications; such biomaterials could, therefore, have major clinical impact.

The seminar will be teleconferenced to SL-220 at IUPUI.

~BME Faculty Host: Dr. Julie Liu~

***Coffee and juice will be provided at West Lafayette***