Biological Sciences Seminar - Wed., Feb. 19
|Event Date:||February 19, 2014|
|Hosted By:||Department of Biological Sciences
|Location:||MJIS 1001, WL campus
Control of cell migration is important for healing of damaged tissues and on the flip side, cell invation is at the root of the challenge that clinicians face in treating brain tumors. In my laboratory, we have been exploring the use of thin film mediated topographical cues to enable efficient and controlled migration of cells. In the peripheral nere context, induction of Schwann cell migration into critically sized nerve gaps enables bridging of long nerve gaps.
In the context of brain tumors, we are designing novel devices to control the invasion of brain tumors along parths that we specify using topographical guidance of brain tumors in vivo. We demonstrate, for the first time to our knowledge, that topographical cues presented by thin films enable moving a primary tumor from an intracortical region to an extracortical hydrogel sink where the tumor cells are killed. This novel approach of bringing the tumor to the drug rather than the drug to the tumor is enabled by our ability to design constructs that enable controlled, directional migration of invasive brain tumors.