Dr. Brown will speak on "Imaging at the Cutting Edge: New Microscopy Strategies for Point-of-Care Cancer Pathology."

Abstract: A number of clinical situations would benefit from a more timely and complete assessment of tissue pathology at the point-of-care, as compared to labor- and time-intensive destructive methods such as frozen section analysis.  High-throughput microscopy of intact core needle biopsies at the patient’s bedside would indicate if additional biopsies are necessary to prevent a false negative procedure.  Rapid non-destructive screening of tumor content would enable clinicians to most efficiently utilize precious cancer tissues for downstream molecular and laboratory analysis, particularly important as new strategies for personalized medicine emerge.  Intraoperative imaging of entire surgically-resected tumors would enable a rapid determination of the presence of residual cancer at the resection margin, in time to correct the surgery and improve post-surgical outcomes.  Our laboratory is seeking to address these challenges with the development of ultra-high-throughput optical sectioning microscopy, combined with novel strategies for fluorescence histochemistry, to contribute practical and clinically-adoptable solutions for point-of-care pathology.  In this talk I will describe the development of these technologies, and their application to rapid diagnosis of prostate core needle biopsies and gigapixel imaging of the entire surfaces of prostate and renal tumor resection specimens.

BME Faculty Host: Craig Goergen~

***Coffee and juice will be provided at West Lafayette***