BME Seminar Series - Wed., Jan. 28
Event Date: | January 28, 2015 |
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Hosted By: | Weldon School of Biomedical Engineering |
Time: | 9:30 a.m. |
Location: | MJIS 1001, WL campus |
Abstract: Adaptive behavior in response to learned environmental cue-salient stimulus associations is one of the basic functions of the brain. However, the neural mechanisms of this learning are not known. We have discovered that neurons in the mouse primary visual cortex (V1) can encode information about the timing of prospective rewards. This phenomenon of “reward timing” requires the actions of the cholinergic system, a known neuromodulation system of visual cortical plasticity, only for the acquisition of new stimulus-reward intervals, but not for the expression, of already entrained intervals. Reward timing can also be recapitulated in vitro by pairing white matter stimulation with muscarinic receptor activation at a target temporal interval. It is input specific and does not depend on changes in input resistance or neuronal excitability suggesting that synaptic plasticity within the cortical circuitry may be the cellular mechanism for modifying persistent activity. To test this hypothesis we have developed an image-guided robotic whole-cell patch clamp technology, which we are planning to use together with Channelrhodopsin-Assisted Circuit Mapping (CRACM) to target specific intra-cortical synaptic connections.
~BME Faculty Host: Ed Bartlett~
***Coffee and juice will be provided at West Lafayette***
(via live streaming in SL165 at IUPUI)
2015-01-28 09:30:00 2015-01-28 10:30:00 America/Indiana/Indianapolis BME Seminar Series - Wed., Jan. 28 Dr. Alex Chubykin of the Department of Biological Sciences at Purdue University will present a seminar on Wednesday, January 28th entitled "Synaptic and Circuit Mechanisms of Reward Timing in the Mouse Visual Cortex." The seminar will begin at 9:30 a.m. in MJIS 1001. MJIS 1001, WL campus