Bio: Dr. Rafael de Cabo's research has focused on the physiological and tissue-specific molecular mechanisms for the effects of caloric restriction on aging, and pharmacological interventions that act on these pathways. Research within his unit strives to identify protective mechanisms invoked by caloric restriction and to evaluate the consequences of dietary interventions on lifespan, pathology, and behavioral function including diabetes.

This seminar is sponsored in part by the Indiana Bioengineering Interdisciplinary Training for Diabetes Research Program (NIH T32) 

To schedule a time to speak with Dr. de Cabo please contact Cindy Ferguson (fergusoc@purdue.edu)

Recent Publications:

1. Ramirez, C. M., Goedeke L., Rotllan N., Yoon J. H., Cirera-Salinas D., Mattison J. A., Suarez Y., de Cabo R., Gorospe M., Fernandez-Hernando C. MicroRNA 33 Regulates Glucose Metabolism. Mol Cell Biol. 2013;33(15):2891-2902. PMCID: 3719675.
2. Shimazu, T., Hirschey M. D., Newman J., He W., Shirakawa K., Le Moan N., Grueter C. A., Lim H., Saunders L. R., Stevens R. D., Newgard C. B., Farese R. V., Jr., de Cabo R., Ulrich S., Akassoglou K., Verdin E. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013; 339(6116):211-214.
3. Mercken, E. M., Crosby S. D., Lamming D. W., Jebailey L., Krzysik-Walker S., Villareal D. T., Capri M., Franceschi C., Zhang Y., Becker K., Sabatini D. M., de Cabo R., Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 2013;12(4):645-651. PMCID: 3714316.
4. Martin-Montalvo, A., Mercken E. M., Mitchell S. J., Palacios H. H., Mote P. L., Scheibye-Knudsen M., Gomes A. P., Ward T. M., Minor R. K., Blouin M. J., Schwab M., Pollak M., Zhang Y., Yu Y., Becker K. G., Bohr V. A., Ingram D. K., Sinclair D. A., Wolf N. S., Spindler S. R., Bernier M., de Cabo R. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013, 4:2192.
5. Mercken, E. M., Hu, J., Krzysik-Walker, S., Wei, M., Li, Y., McBurney, M.W., de Cabo R., Longo, V.D. SIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice. Aging Cell. 2013, 13(1):193-6.
6. Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Egan JM, Baur JA, Ferruci L, Bogan JS, Bernier M, de Cabo R. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metabolism. 2013, 18(4):533-45.
7. Mitchell, Sarah J., Martin-Montalvo, A., Mercken, Evi M., Palacios, Hecto rH., Ward, Theresa M., Abulwerdi, G., Minor, Robin K., Vlasuk, George P., Ellis, James L., Sinclair, David A., Dawson, J., Allison, David B., Zhang, Y., Becker, Kevin G., Bernier, M., de Cabo, R. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet (2014) Cell Reports. 6(5):836-43.
8. Okun, E., Griffioen, K.J., Rothman, S., Wan, R., Cong, W.-N., de Cabo, R., Martin-Montalvo, A., Levette, A., Maudsley, S., Martin, B., Arumugam, T.V., Mattson, M.P. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism (2014) Brain, Behavior, and Immunity, 36, pp. 90-100.
9. Mercken, E.M., Hu, J., Krzysik-Walker, S., Wei, M., Li, Y., Mcburney, M.W., de Cabo, R., Longo, V.D. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice (2014) Aging Cell, 13 (1), pp. 193-196.
10. Gomes, A.P., Price, N.L., Ling, A.J., Moslehi, J.J., Montgomery, M.K., Rajman, L., White, J.P., Teodoro, J.S., Wrann, C.D., Hubbard, B.P., Mercken, E.M., Palmeira, C.M., de Cabo, R., Rolo, A.P., Turner, N., Bell, E.L., Sinclair, D.A. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. (2013) Cell, 155 (7), pp. 1624-1638.
11. López-Domínguez, J.A., Khraiwesh, H., González-Reyes, J.A., López-Lluch, G., Navas, P., Ramsey, J.J., de Cabo, R., Burón, M.I., Villalba, J.M. Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie restricted mice (2013) Age, 35 (6), pp. 2027-2044.
12. Mercken, E.M., Majounie, E., Ding, J., Guo, R., Kim, J., Bernier, M., Mattison, J., Cookson, M.R., Gorospe, M., de Cabo, R., Abdelmohsen, K. Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction (2013) Aging, 5 (9), pp. 692-703.
13. Lee-Chang, C., Bodogai, M., Martin-Montalvo, A., Wejksza, K., Sanghvi, M., Moaddel, R., de Cabo, R., Biragyn, A. Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells (2013) Journal of Immunology, 191 (8), pp. 4141-4151.
14. Fiori, J.L., Shin, Y.-K., Kim, W., Krzysik-Walker, S.M., González-Mariscal, I., Carlson, O.D., Sanghvi, M., Moaddel, R., Farhang, K., Gadkaree, S.K., Doyle, M.E., Pearson, K.J., Mattison, J.A., de Cabo, R., Egan, J.M. Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet (2013) Diabetes, 62 (10), pp. 3500-3513.
15. Mercken, E.M., Mitchell, S.J., Martin-Montalvo, A., Minor, R.K., Almeida, M., Gomes, A.P., Scheibye-Knudsen, M., Palacios, H.H., Licata, J.J., Zhang, Y., Becker, K.G., Khraiwesh, H., González-Reyes, J.A., Villalba, J.M., Baur, J.A., Elliott, P., Westphal, C., Vlasuk, G.P., Ellis, J.L., Sinclair, D.A., Bernier, M., de Cabo, R. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass (2014) Aging Cell. Article in Press.
16. Mitchell, S.J., Martin-Montalvo, A., Mercken, E.M., Palacios, H.H., Ward, T.M., Abulwerdi, G., Minor, R.K., Vlasuk, G.P., Ellis, J.L., Sinclair, D.A., Dawson, J., Allison, D.B., Zhang, Y., Becker, K.G., Bernier, M., de Cabo, R. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet (2014) Cell Reports, 6 (5), pp. 836-843.
17. Mattison, Julie A., Wang, M., Bernier, M., Zhang, J., Park, S.-S., Maudsley, S., An, Steven S., Santhanam, L., Martin, B., Faulkner, S., Morrell, C., Baur, Joseph A., Peshkin, L., Sosnowska, D., Csiszar, A., Herbert, Richard L., Tilmont, Edward M., Ungvari, Z., Pearson, Kevin J., Lakatta, Edward G., de Cabo, R. Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates (2014) Cell Metabolism. Article in Press.