BME Seminar - Wed., December 3
Event Date: | December 3, 2014 |
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Hosted By: | Weldon School of Biomedical Engineering |
Time: | 9:30 a.m. |
Location: | MJIS 1001, WL campus |
Abstract: Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles. Cellular imaging with the immediate early gene c-fos and its protein product Fos has been used to identify sparsely distributed neurons that were strongly activated during conditioned drug-related behaviors. My lab developed a procedure (Daun02 inactivation) that exploits the c-fos promoter in transgenic rats to demonstrate causal roles for Fos-expressing neuronal ensembles in prefrontal cortex and nucleus accumbens in conditioned drug-related behaviors such as drug self-administration and context- and cue-induced reinstatement of drug seeking. We also developed techniques that allowed us to identify unique molecular alterations (using FACS) and electrophysiological alterations (using c-fos-GFP mice and rats) within Fos-expressing neuronal ensembles that may contribute to the development and expression of learned associations in addiction. Now we developed a bitransgenic c-fos-tet-Cre rat system that we have used to assess context and cue selectivity of neuronal ensembles as well as their roles in context-dependent reinstatement of cocaine seeking. We hope that this work will one day permit disruption of specific memories underlying drug relapse in human addicts.
~BME Faculty Host: Jenna Rickus~
***Coffee and juice will be provided at West Lafayette***
(via teleconference to SL165 at IUPUI)
2014-12-03 09:30:00 2014-12-03 10:30:00 America/Indiana/Indianapolis BME Seminar - Wed., December 3 Bruce Hope, Ph.D., Neurobiology of Relapse Section of the National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP)will present a seminar on Wednesday, December 3rd entitled "New technologies for examining neuronal ensembles in addiction." MJIS 1001, WL campus