Using Diffusion Distances for Flexible Molecular Shape Comparison

Using Diffusion Distances for Flexible Molecular Shape Comparison

Yu-shen Liu, Qi Li, Guo-Qin Zheng, Karthik Ramani, and William Benjamin
BMC Bioinformatics 2010, 11:480

Abstract: Background Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat them as rigid bodies, which may lead to incorrect shape...

Integrated Sustainable Lifecycle Design: A Review

Integrated Sustainable Lifecycle Design: A Review

Karthik Ramani, Devarajan Ramanujan, William Z Bernstein, Fu Zhao, John Sutherland, Carol Handwerker, Jun-Ki Choi, Harrison Kim, and Deborah Thurston
Published in the Journal of Mechanical Design, Sept. 2010, Vol. 132, No. 9, pp. 1-15.

Abstract:  Product design is one of the most important sectors influencing global sustainability, as almost all the products consumed by people are outputs of the product development process. In particular, early design decisions can have a very...

A Port-based Agent Approach to Guiding Concept Generation for Customizing Modular Varieties

A Port-based Agent Approach to Guiding Concept Generation for Customizing Modular Varieties

Dongxing Cao, Karthik Ramani, Ming Wang Fu, and Runli Zhang
in Proceedings of the ASME 2010 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference IDETC/CIE 2010 August 15-18, 2010, Montreal, Quebec, Canada

Abstract: As the description of design requirements at the earlier design stage is inaccurate and vague, it is difficult to figure out functional structure of a product and make sense product configuration. Therefore, it plays an important role to...

Understanding Innovation in Student Design Projects

Understanding Innovation in Student Design Projects

Luis A. Elizondo, Lorraine G. Kisselburgh, E. Daniel Hirleman, Raymond Cipra, Karthik Ramani, Maria Yang, and Tamara Carleton
Proceedings of the ASME 2010 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference IDETC/CIE 2010 August 15-18, 2010, Montreal, Quebec, Canada

Abstract: Over the past few years, academic institutions have become aware of the importance of innovation in education, as well as its broader role in strengthening the economy. Creativity and innovative thinking are not easily taught in the...

Developing Customer Preferences for Concept Generation by Using Engineering Ontologies

Developing Customer Preferences for Concept Generation by Using Engineering Ontologies

Dongxing Cao , Karthik Ramani , Zhanjun Li , Victor Raskin , Ying Liu , and Zhanwei Li
Proceedings of the ASME 2010 IDETC/CIE August 15-18, 2010, Montreal, Quebec, Canada

Abstract: As customer preference is viewed as a reflection of desires for product features and even future product opportunities, it is crucial for the generation of design concepts. In this paper, a six-stage methodology is described for...

Integration of Sustainability Into Early Design through the Function Impact Matrix

Integration of Sustainability Into Early Design through the Function Impact Matrix

Srikanth Devanathan, Devarajan Ramanujan, William Z Bernstein, Fu Zhao, and Karthik Ramani
Journal of Mechanical Design, August 2010, Vol. 132, No. 8, pp. 1-8.

Abstract: The issue of environmental sustainability, which is unprecedented in both magnitude and complexity, presents one of the biggest challenges faced bymodern society. Design engineers can make significant contributions by...

PCS: Prominent Cross-Sections for Mesh Models

PCS: Prominent Cross-Sections for Mesh Models

Subramani Sellamani, Ramanathan Muthuganapathy, Yagnanarayanan Kalyanaraman, Sundar Murugappan, Manish Goyal, Karthik Ramani, and Christoph M. Hoffman
Computer Aided Design and Applications (CADA), Volume 7, Number 4, Pages 601-620, 2010

Abstract: Analysis of mesh models is gaining prominence as it has wide range of applications from engineering to medicine. In this paper, we present a method for analyzing meshes through the abstraction of its prominent cross-sections (PCS). An...

Development of a Framework for Sustainable Conceptual Design

Development of a Framework for Sustainable Conceptual Design

William Z Bernstein, Devarajan Ramanujan, Srikanth Devanathan, Fu Zhao, Karthik Ramani, and John W. Sutherland
Proceedings of the 17th CIRP International Conference on Life Cycle Engineering.

Abstract: The cost and environmental impacts of a product are largely determined during conceptual design. Most often, due to cost and time limitations, only a limited set of design concepts are carried forward for detailed design. As a result,...